Atrial Natriuretic Factor (1-29) (chicken) CAS NO.118691-45-5
Atrial Natriuretic Factor (1-29) (chicken) CAS NO.118691-45-5
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Atrial Natriuretic Factor (1-29) (chicken) |
| CAS NO. | 118691-45-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C124H211N47O40S5 |
| Molecular Weight | 3160.7g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate-buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). For stock solution, dissolve in 0.1% acetic acid or sterile water at 0.1–1.0 mg/mL. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Chicken ANF (1–29) binds to natriuretic peptide receptors (primarily NPR‑A) and activates guanylyl cyclase, increasing intracellular cGMP levels. This leads to vasodilation, natriuresis, and diuresis. Activity can be confirmed by cGMP accumulation assays or vascular relaxation bioassays. |
| Storage Conditions | Lyophilized powder: Store desiccated at –20°C or below, protected from light. Reconstituted solution: Aliquot and store at ≤–20°C; avoid repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its biological effects by binding to natriuretic peptide receptors, primarily NPR-A, which are transmembrane guanylyl cyclase-coupled receptors expressed in cardiovascular tissues, kidneys, and other target organs. Receptor activation stimulates intracellular guanylyl cyclase activity, leading to increased production of cyclic GMP (cGMP) and activation of cGMP-dependent protein kinases. This signaling cascade results in vasodilation, enhanced renal sodium and water excretion (natriuresis and diuresis), and suppression of the renin-angiotensin-aldosterone system. The peptide's conserved disulfide bond structure is essential for maintaining its bioactive conformation and ensuring high-affinity receptor interaction and downstream physiological responses.
2.PRODUCT INDICATIONS
This chicken ANF (1-29) peptide is indicated for research use only in preclinical investigations of cardiovascular and renal physiology, hypertension, heart failure, and fluid-electrolyte homeostasis. It is utilized as a specific agonist in receptor-binding assays, cGMP accumulation studies, and in vitro models of vascular relaxation and renal function. The peptide is also employed in comparative studies across species to understand evolutionary aspects of natriuretic peptide systems and in animal models to evaluate hemodynamic and natriuretic responses. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, Atrial Natriuretic Factor (1-29) (chicken) does not have established clinical efficacy for therapeutic use in human patients. This synthetic peptide has not undergone clinical development or received regulatory approval for any medical indication. While natriuretic peptides, including avian variants, have been studied in preclinical models for their cardiovascular and renal effects, the product itself remains an investigational tool for basic and translational research. It has no proven clinical efficacy or safety profile in humans and is strictly intended for laboratory research applications.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Nov 05, 26
Global Market Analysis and Oxandrolone 50mg Price Guide
For B2B pharmaceutical buyers and researchers, understanding the oxandrolone 50mg price involves analyzing more than just a numerical value; it requires a comprehensive look at API purity, synthesis methods, and global supply chain stability. As a specialized anabolic steroid derivative, the cost is heavily influenced by the quality of raw materials and the rigor of the laboratory testing involved in the production process. This article explores the economic and technical variables that dictate market pricing for this specific compound. In the context of the global API market, pricing volatility is often tied to regulatory shifts in key manufacturing hubs
Nov 04, 26
How to Select High Purity Alisol C CAS 30489271 for Laboratory Research
High Purity Alisol C CAS 30489271 is suited to laboratories using Alisol C as a triterpenoid reference standard in metabolic, hepatology, pharmacology, HPLC/MS, botanical-extract, or selected cell-line research. We explain the application fit and the identity, purity, physical form, solvent, endotoxin, storage, quantity, and batch-record checks to make before ordering.
Nov 02, 26
Reliable Oxandrolone Supplier for High Purity Pharmaceutical APIs
When sourcing high-purity pharmaceutical ingredients for endocrine or cardiovascular research, the reliability of the supply chain is as critical as the chemical purity itself. For laboratories and manufacturers seeking a dependable oxandrolone supplier, the focus must extend beyond simple certificates of analysis to encompass consistent batch-to-batch stability and strict adherence to GMP standards. Whether the requirement is for small-scale pilot studies or large-scale industrial production, the ability to trace materials from raw synthesis to final lyophilized powder ensures the integrity of the resulting clinical or research data.