Atrial Natriuretic Factor (4-28) (human) CAS NO.95896-08-5

Atrial Natriuretic Factor (4-28) (human) (CAS NO. 95896-08-5) is a synthetic peptide fragment corresponding to amino acid residues 4-28 of the human atrial natriuretic peptide (ANP/ANF). This high-purity, 25-amino acid sequence represents a truncated yet biologically active form of the hormone and serves as a crucial research tool for studying the structure-activity relationships and specific cardiovascular effects of the ANP family.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Atrial Natriuretic Factor (4-28) (human)
CAS NO.	95896-08-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C112H175N39O35S3
Molecular Weight	2724.06g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in water, or dilute acetic acid; sparingly soluble in methanol
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist for natriuretic peptide receptor-A (NPR-A); EC₅₀ ≈ 0.3–1.2 nM in cGMP accumulation assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark environment.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide fragment retains the core structural ring formed by a disulfide bond, which is essential for receptor binding and biological activity. It functions as an agonist for the natriuretic peptide receptor A (NPR-A/GC-A).

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in cardiovascular physiology, nephrology, and endocrinology. Primary applications include: studying the minimal active structure of ANP, investigating receptor binding affinity and selectivity, serving as a reference standard in cGMP stimulation and receptor binding assays, and exploring the cardiovascular and renal effects of ANP fragments in preclinical models of hypertension, heart failure, and fluid-electrolyte balance.

3.CLINICAL EFFICACY OF PRODUCT

Atrial Natriuretic Factor (4-28) (human) is a research-grade peptide and not an approved therapeutic. Its "efficacy" lies in its significant scientific value for understanding the ANP system. Research utilizing this and similar fragments has been pivotal in identifying the core receptor-binding domain of ANP, which directly informed the development of clinically relevant analogs and drugs targeting the natriuretic peptide pathway .

4.DELIVERY & SHIPPING

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