Biotin-Atrial Natriuretic Peptide (1-28), human, porcine

Biotin-Atrial Natriuretic Peptide (1-28), human, porcine is a synthetic, biotin-conjugated analog of the full-length, bioactive 28-amino acid atrial natriuretic peptide (ANP). This high-purity, dual-functional reagent preserves the native biological activity of ANP while incorporating a biotin tag, enabling its specific capture, detection, and immobilization in streptavidin-based assay systems for advanced cardiovascular and receptor research.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-Atrial Natriuretic Peptide (1-28), human, porcine
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C137H217N47O41S4
Molecular Weight	308.8/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in water, or dilute acetic acid
Endotoxin	≤1.0 /mg
Biological Activity	Potent agonist for natriuretic peptide receptor-A (NPR-A); EC₅₀ ≈ 0.2–1.0 nM in cGMP accumulation assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark environment. After reconstitution, store at 4°C for up to 1 week or ≤ -20°C for long-term storage. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This conjugate functions as a full agonist for the natriuretic peptide receptor A (NPR-A/GC-A). The biotin moiety, attached via a linker, does not interfere with the peptide's core structure necessary for receptor binding. Upon binding to NPR-A, it activates the receptor's intrinsic guanylyl cyclase activity, leading to increased intracellular cyclic guanosine monophosphate (cGMP) production.

2.PRODUCT INDICATIONS

This product is indicated for sophisticated research applications in molecular pharmacology and assay development. Key uses include: immobilization for surface plasmon resonance (SPR) or biolayer interferometry (BLI) to study ANP-NPR-A binding kinetics, pull-down assays to isolate and identify receptor complexes or interacting proteins, development of sensitive ELISA or other immunoassays for ANP detection, and as a probe for receptor localization studies using streptavidin-based detection methods.

3.CLINICAL EFFICACY OF PRODUCT

Biotin-ANP (1-28) is a research tool, not a therapeutic. Its efficacy is defined by its critical role in enabling high-precision analytical techniques. By facilitating detailed biophysical and biochemical studies of the ANP-NPR-A interaction, this reagent contributes to the fundamental understanding of natriuretic peptide signaling.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.