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[Tyr0] – Neurokinin CAS NO.116868-93-0

[Tyr0] – Neurokinin (CAS NO. 116868-93-0) is a synthetic, N-terminally extended analog of the endogenous neuropeptide Substance P (Neurokinin P). This research-grade peptide features an additional tyrosine residue at the N-terminus (position 0), which facilitates radiolabeling with iodine-125 (¹²⁵I) for sensitive detection and binding assays.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Tyr⁰]-Neurokinin
CAS NO.	116868-93-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C59H89N15O16S
Molecular Weight	1296.52/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in water, or dilute acetic acid
Endotoxin	≤1.0 EU/mg
Biological Activity	This peptide segment is a prohormone region of ANF and does not exhibit direct vasoactive activity.
Storage Conditions	Store at ≤ -20°C in a dry, dark environment.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as a high-affinity agonist for tachykinin receptors, particularly the neurokinin 1 (NK1) receptor. The addition of the tyrosine residue does not significantly alter its core receptor-binding domain or biological activity. Upon binding to NK1 receptors, which are predominantly expressed in the central and peripheral nervous systems, it activates Gq protein-coupled signaling.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in neuropharmacology, receptor biology, and signal transduction. Its primary applications include: radioligand binding assays (after iodination with ¹²⁵I) for studying NK1 receptor density and pharmacology, investigating tachykinin receptor-mediated functions in pain, inflammation, and emesis, serving as a standard or agonist control in functional assays (e.g., calcium flux), and exploring the role of Substance P in neurological and inflammatory disorders.

3.CLINICAL EFFICACY OF PRODUCT

[Tyr0] - Neurokinin is a vital research probe, not a therapeutic. Its "efficacy" is defined by its utility in fundamental and translational science. As a key radioligand precursor, it has been indispensable for mapping NK1 receptor distribution in tissues and characterizing novel NK1 receptor antagonists. This foundational research directly enabled the development of clinical drug candidates targeting the NK1 receptor for conditions such as chemotherapy-induced nausea and vomiting (e.g., aprepitant), depression, and chronic pain.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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