[β-Ala8]-Neurokinin A (4-10)

[β-Ala8]-Neurokinin A (4-10) is a synthetic, modified tachykinin peptide fragment and a stabilized analog of Neurokinin A (NKA). This research-grade compound features a β-alanine substitution at position 8, which enhances its metabolic stability against enzymatic degradation. It is a selective and potent agonist for the Neurokinin 2 (NK2) receptor, making it a valuable tool for studying tachykinin signaling, smooth muscle physiology, and peptide structure-activity relationships.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[β-Ala⁸]-Neurokinin A (4-10)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C35H56N8O10S
Molecular Weight	781 /mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid and DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent and selective agonist for neurokinin-2 (NK2) receptors
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog acts as a potent and selective agonist for the Neurokinin 2 (NK2) receptor. The incorporation of β-alanine at position 8 increases resistance to peptidase cleavage, prolonging its biological activity. Upon binding to the NK2 receptor, it activates the associated Gq protein, triggering the phospholipase C (PLC) pathway.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in pharmacology, smooth muscle physiology, and neurobiology. Key applications include: investigating the role of NK2 receptors in bronchoconstriction, gastrointestinal motility, and bladder function; serving as a stable reference agonist in functional assays using isolated tissue preparations.

3.CLINICAL EFFICACY OF PRODUCT

[β-Ala8]-Neurokinin A (4-10) is a research tool, not a clinical therapeutic. Its efficacy is defined by its utility as a robust and stable pharmacological probe. Research utilizing this analog has been instrumental in delineating the specific physiological roles of NK2 receptor signaling.

4.DELIVERY & SHIPPING

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