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[Nle10]-Neurokinin A (4-10)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Nle¹⁰]-Neurokinin A (4‑10) |
| CAS NO. | |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C35H56N8O10 |
| Amino Acid Sequence | H‑His‑Lys‑Thr‑Asp‑Ser‑Phe‑Nle‑NH₂ (Neurokinin A residues 4‑10 with norleucine at position 10) |
| Molecular Weight | 748.88g/mol |
| Purity (RP-HPLC) | ≥97.0% (typical for research peptides) |
| Solubility | Soluble in water, 0.1 M acetic acid, or phosphate‑buffered saline (PBS) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Modified tachykinin peptide; selective agonist for the NK₂ receptor, used in studies of smooth muscle contraction, airway reactivity, and neurokinin receptor signaling. |
| Storage Conditions | Store at –20 °C, protected from light and moisture. For long‑term storage, recommend –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
[Nle¹⁰]-Neurokinin A (4-10) acts as a selective agonist for the neurokinin‑2 (NK₂) receptor. By binding to NK₂ receptors, it initiates intracellular signaling cascades, such as phospholipase C activation and calcium mobilization, leading to physiological responses including smooth muscle contraction and neuronal excitation.
2.PRODUCT INDICATIONS
This peptide is used in research on smooth muscle physiology, airway reactivity, gastrointestinal motility, and pain signaling. It is also applied in drug‑discovery assays for NK₂ receptor‑targeting compounds and in studies of inflammatory and respiratory disorders.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical studies demonstrate that [Nle¹⁰]-Neurokinin A (4-10) effectively induces smooth muscle contraction and modulates airway responsiveness in experimental models. While not a therapeutic itself, it provides a valuable tool for validating NK₂ receptor pathways and supporting the development of novel therapeutics for conditions like asthma, irritable bowel syndrome, and chronic pain.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
