Neuromedin N CAS NO.92169-45-4

[Pro⁷]-Neuromedin N (CAS NO. 92169-45-4) is a synthetic, site-specifically modified analog of the endogenous neuropeptide Neuromedin N. This research-grade peptide features a proline substitution at position 7, which introduces a conformational constraint within its structure. This modification is designed to study the impact of backbone rigidity on the peptide's biological activity, stability, and receptor interaction profile, making it a specialized tool for neuropeptide research and drug design.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuromedin N
CAS NO.	92169-45-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C38H63N7O8
Molecular Weight	745.97/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist for neurotensin receptor 1 (NTS1) and neurotensin receptor 2 (NTS2); exhibits high binding affinity with EC₅₀ ≈ 0.4–2.5 nM in calcium mobilization assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog acts as a ligand for neurotensin receptors (NTS1 and NTS2). The incorporation of proline at position 7 alters the peptide's secondary structure by creating a potential kink or turn, which can significantly modulate its binding affinity and selectivity for these G protein-coupled receptors compared to native Neuromedin N.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in neuropharmacology, gastroenterology, and peptide chemistry. Key applications include: investigating the structural determinants of Neuromedin N's activity through structure-activity relationship (SAR) studies, studying the role of neurotensin receptor subtypes in gastrointestinal function and pain modulation, evaluating the effects of conformational constraints on peptide stability and receptor selectivity, and serving as a precursor for developing novel, stabilized neurotensin receptor ligands.

3.CLINICAL EFFICACY OF PRODUCT

[Pro⁷]-Neuromedin N is a research compound, not a direct therapeutic. Its efficacy is demonstrated in its role as a molecular probe for peptide engineering. Studies utilizing such analogs are critical for understanding how specific amino acid substitutions influence peptide conformation, receptor interaction, and metabolic stability. This knowledge is foundational for the rational design of peptide-based therapeutics with improved pharmacokinetic and pharmacodynamic properties, potentially for conditions like irritable bowel syndrome (IBS), chronic pain, or psychiatric disorders where neurotensin signaling is implicated.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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