Neuromedin U, rat CAS NO.117505-80-3
Neuromedin U, rat CAS NO.117505-80-3
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neuromedin U, rat |
| CAS NO. | 117505-80-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C124H180N34O31 |
| Molecular Weight | 2643.03 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1 % v/v). It is recommended to first dissolve in a small volume of 0.1 % acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Neuromedin U is an endogenous neuropeptide that acts as a potent agonist at the neuromedin U receptors (NMUR1 and NMUR2). It regulates diverse physiological functions including smooth muscle contraction, energy homeostasis, appetite suppression, stress response, and circadian rhythms. Activity can be confirmed in NMUR-expressing cell-based assays (e.g., calcium flux or cAMP inhibition) or in bioassays measuring ileal or uterine smooth muscle contraction. |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its biological effects by binding with high affinity to G protein-coupled receptors NMUR1 and NMUR2, primarily coupling to Gq/11 proteins. Activation of these receptors stimulates phospholipase C, leading to inositol trisphosphate (IP3) production and intracellular calcium mobilization. This signaling cascade modulates various downstream pathways, including smooth muscle contraction, inhibition of cAMP accumulation, and regulation of neurotransmitter release. The rat isoform exhibits species-specific potency and is particularly valuable for studying NMU receptor pharmacology in rodent models.
2.PRODUCT INDICATIONS
Neuromedin U, rat is indicated exclusively for research applications in preclinical studies of neuropeptide signaling and physiology. It is employed to investigate the roles of NMU in appetite regulation, energy expenditure, gastrointestinal motility, uterine contraction, and stress-induced behaviors. The product serves as a reference agonist for validating NMUR1/NMUR2 expression, screening receptor antagonists, and characterizing NMU signaling pathways in cell-based assays and animal models. It is not intended for diagnostic, therapeutic, or clinical use in humans.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, Neuromedin U, rat has no established clinical efficacy or safety profile for therapeutic applications in humans. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of NMU biology and potential therapeutic targets for obesity, gastrointestinal disorders, and metabolic diseases, its utility remains confined to laboratory research. Any translation to clinical applications would require development of human-specific analogs with comprehensive preclinical and clinical testing.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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