Biotin-Neuromedin B
Biotin-Neuromedin B
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-Neuromedin B |
| CAS NO. | |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C62H87N17O14S2 |
| Molecular Weight | 1358.62g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution, then dilute with assay buffer. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Biotin-Neuromedin B is a conjugated analog of the endogenous bombesin-related peptide. It retains high affinity for the neuromedin B receptor (NMBR, BB1), allowing its use as a probe in receptor binding studies, pull-down assays, and immunohistochemistry when paired with streptavidin detection systems. Activity should be validated in relevant NMBR binding or functional assays. |
| Storage Conditions | Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80°C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide functions as a high-affinity agonist for the neuromedin B receptor (NMBR), a G protein-coupled receptor that primarily couples to Gq/11 proteins. Binding to NMBR activates phospholipase C, leading to inositol trisphosphate (IP3) production, intracellular calcium mobilization, and downstream signaling events involved in smooth muscle contraction, cell proliferation, and neuroendocrine regulation. The biotin moiety does not interfere with receptor engagement but provides a handle for streptavidin-mediated detection and capture, facilitating visualization and isolation of receptor-ligand complexes.
2.PRODUCT INDICATIONS
Biotin-Neuromedin B is indicated exclusively for research applications in studies of bombesin receptor biology and signaling. It is employed for NMBR binding assays, receptor autoradiography, pull-down and affinity purification of receptor complexes, immunohistochemistry, flow cytometry, and cellular imaging in both fixed and live-cell systems. The product serves as a critical tool for mapping NMBR expression, validating receptor antibodies, and screening modulators of bombesin receptor signaling pathways. It is not intended for diagnostic, therapeutic, or clinical use in humans.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, Biotin-Neuromedin B has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of NMBR biology and potential therapeutic targets in cancer, gastrointestinal disorders, and metabolic diseases, its utility remains confined to laboratory research. Any translation to clinical applications would require development of unmodified therapeutic analogs with comprehensive preclinical and clinical testing.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
May 25, 26
Premium API Oxandrolone Ucinky Manufacturing
Premium API Oxandrolone Ucinky Manufacturing Leading global supplier of high-purity chemical raw materials for pharmaceutical grade Oxandrolone Ucinky, combining precision engineering with industrial scale. 5000 kg Annual Output 120 Countries Served 5 Days Sample Lead Time 99.7 On-Time Delivery Industrial Precision Pure Chemical Synthesis Engineering the future of pharmaceutical intermediates with unmatched stability. Our facility stands as a global leader in the oxandrolone ucinky sector, utilizing CRYOGENIC CRYSTALLIZATION and advanced chromatography to ensure an assay purity exceeding 99.8. We integrate a fully automated closed-loop system that eliminates human error and contamination.
May 22, 26
Clinical Benefits and Applications of Oxandrolone Therapy
Oxandrolone therapy represents a sophisticated intersection of endocrine science and regenerative medicine, primarily utilized to address muscle wasting and metabolic dysfunction. In the global pharmaceutical landscape, this specific approach to androgen therapy is valued for its unique ability to promote protein synthesis while exhibiting a lower androgenic profile compared to traditional steroids, making it a critical tool for patients recovering from severe trauma or chronic illness. From a clinical perspective, understanding the nuances of oxandrolone therapy is essential for optimizing patient outcomes in weight gain and tissue repair.
May 20, 26
Clinical Benefits and Production of Oxandrolone Steroid
The global pharmaceutical landscape has seen a significant rise in the demand for highly specialized anabolic agents, among which the oxandrolone steroid stands out due to its unique chemical profile and therapeutic versatility. As a modified version of dihydrotestosterone, this compound provides a potent means of addressing muscle wasting and metabolic deficits, making it a critical asset in both clinical rehabilitation and advanced physiological research. Understanding the nuances of this synthetic compound is essential for healthcare providers and researchers alike, as it balances efficacy with a relatively lower androgenic profile compared to other steroids.
