Biotin-Neuromedin S (human)

Biotin-Neuromedin S (human) is a synthetic, biotin-conjugated form of the human neuromedin S (NMS) peptide. This high-purity, dual-functional research reagent retains the full biological activity of native NMS while being covalently linked to a biotin molecule. This modification enables its specific capture, immobilization, and sensitive detection using streptavidin-based systems, making it an invaluable tool for advanced molecular interaction and receptor studies within the neuromedin signaling pathway

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-Neuromedin S (human)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C67H87N15O14
Molecular Weight	1326.53/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist for neuromedin U receptors (NMU1/NMU2) with retained native bioactivity, EC₅₀ ≈ 0.2–1.8 nM in calcium mobilization assays
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This conjugate functions as a full agonist for the neuromedin U receptor 2 (NMUR2), which is predominantly expressed in the central nervous system. The biotin tag, attached via a flexible linker, does not interfere with the peptide's core receptor-binding domain. Upon binding to NMUR2, it activates the associated Gq protein, triggering the phospholipase C (PLC) pathway.

2.PRODUCT INDICATIONS

This product is indicated for sophisticated research in neurobiology, circadian biology, and assay development. Key applications include: immobilization on streptavidin-coated surfaces for surface plasmon resonance (SPR) or biolayer interferometry (BLI) to study NMS-NMUR2 binding kinetics, pull-down assays to isolate and identify the NMUR2 receptor complex or interacting proteins, development of sensitive detection assays (e.g., ELISA) for NMS, and receptor localization studies using streptavidin-biotin visualization techniques.

3.CLINICAL EFFICACY OF PRODUCT

Biotin-Neuromedin S (human) is a research probe, not a therapeutic agent. Its efficacy is defined by its utility in enabling high-precision analytical techniques. By facilitating detailed biophysical and biochemical studies of the NMS-NMUR2 interaction, this reagent contributes to the fundamental understanding of this signaling pathway's role in regulating circadian rhythms, energy homeostasis, and stress.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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