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[Leu116]-Prepro-Neuromedin U (104-136) (human) CAS NO.1816939-42-0

[Leu¹¹⁶]-Prepro-Neuromedin U (104-136) (human) is a site-specifically modified fragment of the human prepro-NMU precursor, encompassing residues 104-136 with a leucine substitution at position 116. This research-grade peptide is synthesized as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels, designed to investigate the structural and functional role of specific residues in prepro-NMU processing, stability, and potential interaction with processing enzymes. It serves as a critical tool for structure-function studies, epitope mapping, and understanding how single amino acid modifications influence precursor maturation and the generation of bioactive neuromedin U peptides in human-relevant systems.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Leu116]-Prepro-Neuromedin U (104-136) (human)
CAS NO.	1816939-42-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C177H276N46O45
Molecular Weight	3768.45g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). For best results, first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–0.5 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide is a modified fragment of the human prepro-Neuromedin U precursor. The Leu¹¹⁶ substitution may be designed to study the role of specific residues in precursor processing, stability, or receptor interaction. It may contain sequences relevant to neuromedin U bioactivity, but its primary use is for structure-function or processing studies rather than direct receptor activation.
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

As a precursor fragment with a targeted Leu¹¹⁶ substitution, this peptide does not directly activate NMU receptors but functions primarily as a substrate for proteolytic processing enzymes such as prohormone convertases. The leucine modification may alter cleavage kinetics, stability, or interaction with chaperones involved in precursor maturation, thereby influencing the efficiency of bioactive NMU generation. Its mechanism centers on serving as a molecular probe to dissect how specific residues within the prepro-NMU sequence contribute to processing fidelity, peptide folding, and potential interactions with processing machinery, rather than initiating direct receptor-mediated signaling cascades.

2.PRODUCT INDICATIONS

This modified precursor fragment is indicated exclusively for research applications focused on the structure-function analysis of human prepro-Neuromedin U. It is employed to study the impact of specific amino acid substitutions on precursor processing, stability, epitope recognition, and antibody development. The product serves as a reference substrate for validating processing enzyme specificity, characterizing mutant precursor fragments, and investigating disorders associated with impaired neuropeptide biosynthesis. It is not intended for diagnostic, therapeutic, or clinical use in humans or any direct receptor activation studies.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, [Leu¹¹⁶]-Prepro-Neuromedin U (104-136) (human) has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of NMU precursor biology and may inform therapeutic strategies targeting peptide processing pathways in metabolic or gastrointestinal disorders, its utility remains confined to laboratory research. Any clinical translation would require development of entirely distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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