Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2 CAS NO.99566-27-5

Neuropeptide FF (F-8-F-NH₂) (CAS NO. 99566-27-5), also known as Morphine-Modulating Neuropeptide, is a synthetic amidated octapeptide (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH₂) belonging to the RFamide neuropeptide family. This high-purity research tool is an endogenous neuromodulator known for its complex role in pain modulation, opioid tolerance, and various autonomic functions, making it essential for neuropharmacological research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide FF, Morphine Modulating Neuropeptide F-8-F-NH2
CAS NO.	99566-27-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C54H76N14O10
Molecular Weight	1081.3/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & dimethyl sulfoxide
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent morphine-modulating neuropeptide; acts as a key regulator of opioid receptor signaling, EC₅₀ ≈ 0.4–2.2 nM in neuropeptide FF receptor (NPFFR1/NPFFR2) binding assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuropeptide FF primarily exerts its effects by activating two G protein-coupled receptors, NPFF1 and NPFF2. Its action is characterized by a modulatory interplay with the opioid system. It can produce both anti-opioid and pro-opioid effects depending on the dose, site of administration, and physiological context. The peptide generally inhibits the analgesic effects of morphine (anti-opioid effect) and can induce hyperalgesia.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in neuropharmacology and pain biology. Key applications include: studying the mechanisms of opioid tolerance, dependence, and withdrawal; investigating the complex modulation of pain perception and nociception; exploring its roles in cardiovascular regulation, feeding behavior, and insulin release; and serving as a reference agonist in receptor binding and functional assays for NPFF receptor characterization and drug discovery.

3.CLINICAL EFFICACY OF PRODUCT

Neuropeptide FF (F-8-F-NH₂) is a fundamental research probe, not a clinical therapeutic. Its "efficacy" is demonstrated in preclinical studies that have been critical in identifying it as a key endogenous modulator of opioid function. Research using this peptide has significantly advanced the understanding of opioid tolerance mechanisms. This knowledge is crucial for the development of novel therapeutic strategies aimed at preventing or reversing opioid tolerance, potentially improving the long-term management of chronic pain and addressing the opioid crisis.

4.DELIVERY & SHIPPING

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Shipping Methods
Main Method: International Air Freight

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