Neuropeptide W-30 (human) CAS NO.383415-80-3

Neuropeptide W-30 (human) is a 30-amino acid neuropeptide derived from the human prepro-NPW precursor, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide features a C-terminal amidation essential for full biological activity and serves as a potent endogenous ligand for NPBWR1 (GPR7) and NPBWR2 (GPR8) receptors. It is designed for investigating NPW signaling pathways in appetite regulation, energy homeostasis, stress responses, pain modulation, and reproductive neuroendocrine function, providing a standardized tool for both in vitroand in vivostudies in human-relevant systems.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide W-30 (human)
CAS NO.	383415-80-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C165H249N49O37S
Molecular Weight	3543.17 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid (e.g., 0.1% v/v), or phosphate-buffered saline (PBS). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Human Neuropeptide W-30 is an endogenous ligand for the G protein-coupled receptors NPBWR1 (GPR7) and NPBWR2 (GPR8). It is involved in regulating diverse physiological functions, including appetite and energy homeostasis, stress responses, pain modulation, and reproductive hormone secretion. Bioactivity is typically confirmed through receptor binding assays (e.g., competitive binding to NPBWR1) or functional assays (e.g., inhibition of forskolin-stimulated cAMP accumulation in NPBWR1-expressing cells).
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuropeptide W-30 exerts its effects by binding with high affinity to the G protein-coupled receptors NPBWR1 and NPBWR2, primarily coupling to Gi/o proteins to inhibit adenylate cyclase and reduce intracellular cAMP levels. This signaling cascade modulates downstream effectors including potassium channels and MAPK pathways, leading to altered neuronal excitability and neurotransmitter release. The peptide's conserved structure and amidated C-terminus are critical for receptor recognition, resulting in physiological responses such as appetite suppression, stress axis activation, and nociceptive modulation through central and peripheral nervous system pathways.

2.PRODUCT INDICATIONS

This NPW-30 peptide is indicated exclusively for research applications focused on human neuropeptide W signaling. It is employed in receptor binding assays, functional studies measuring cAMP inhibition, appetite and energy balance research, stress response investigations, pain perception models, and reproductive neuroendocrine studies. The product serves as a reference agonist for validating NPBWR1/2 receptor expression, screening receptor antagonists, and studying NPW's role in metabolic disorders, anxiety, and nociception. It is not intended for diagnostic, therapeutic, or clinical use in humans or animals.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Neuropeptide W-30 (human) has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of NPW biology and may inform therapeutic strategies targeting NPBWR receptors for obesity, stress-related disorders, or pain management, its utility remains confined to laboratory research. Any clinical translation would require development of entirely distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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