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Neuropeptide Y (free acid) (human)

Neuropeptide Y (free acid) (human) is a synthetic 36-amino acid peptide representing the full-length human neuropeptide Y (NPY) in its C-terminal free acid form. Unlike the common amidated version, it lacks the C-terminal amidation group. This high-purity variant is a specialized research-grade reagent used to study the effects of this specific post-translational modification on NPY's stability, receptor binding affinity, and biological activity.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide Y (free acid) (human)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C189H284N54O58S1
Molecular Weight	4272.8/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent endogenous agonist for Y1/Y2/Y4/Y5 neuropeptide Y receptors.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide acts as a ligand for the Y-family of G protein-coupled receptors (Y1, Y2, Y4, Y5, Y6). The lack of a C-terminal amide group (free acid form) significantly reduces its receptor binding affinity and biological potency compared to the amidated, native form of NPY. This is because the amide is critical for high-affinity interaction with NPY receptors.

2.PRODUCT INDICATIONS

This product is indicated for specialized research in neuropharmacology, peptide chemistry, and structure-activity relationship (SAR) studies. Key applications include: investigating the role of C-terminal amidation in peptide hormone function and stability, studying the enzymatic processing and degradation pathways of NPY, serving as a precursor or reference compound in the synthesis and characterization of NPY analogs, and as a control in assays comparing the activity of amidated vs. non-amidated NPY forms.

3.CLINICAL EFFICACY OF PRODUCT

Neuropeptide Y (free acid) is a research compound, not a clinical therapeutic. Its efficacy lies in its utility as a precise scientific probe. By comparing the activity of this free acid form to the amidated NPY, researchers can quantify the profound impact of a single post-translational modification on peptide function.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.