Neuropeptide W-30 (rat) CAS NO.383415-90-5

Neuropeptide W-30 (rat) (CAS NO. 383415-90-5) is a synthetic, 30-amino acid peptide representing the endogenous rat isoform of neuropeptide W (NPW). This high-purity, research-grade peptide is a potent endogenous ligand for the G protein-coupled receptors NPBWR1 (GPR7) and NPBWR2 (GPR8). It is a critical tool for studying its diverse roles in regulating energy homeostasis, stress responses, neuroendocrine function, and pain modulation within rodent models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide W-30 (rat)
CAS NO.	383415-90-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C165H249N49O38S
Molecular Weight	3559.17/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & dimethyl sulfoxide
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent and selective agonist for rat G-protein coupled receptors GPR7 and GPR8 (NPW receptors); EC₅₀ ≈ 0.2–1.8 nM in calcium mobilization and cAMP modulation assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide exerts its physiological effects by binding to and activating two cognate receptors, NPBWR1 (GPR7) and NPBWR2 (GPR8), with high affinity. Receptor activation primarily couples to the Gi/o protein signaling pathway, leading to inhibition of adenylate cyclase activity and a subsequent decrease in intracellular cyclic adenosine monophosphate (cAMP) levels.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in neuroendocrinology, metabolism, and behavioral neuroscience using rat models. Key applications include: investigating the role of NPW in appetite regulation, body weight control, and energy balance; studying its involvement in stress, anxiety, and depressive-like behaviors; exploring its effects on pain perception and modulation; and serving as a reference agonist in receptor binding and functional assays (e.g., cAMP inhibition) for NPBWR1/NPBWR2.

3.CLINICAL EFFICACY OF PRODUCT

Neuropeptide W-30 (rat) is a preclinical research tool and not a direct human therapeutic. Its "efficacy" is defined by its vital role in elucidating the complex biology of the NPW system in rodent models. Research utilizing this peptide has been instrumental in identifying NPW as a significant anorexigenic (appetite-suppressing) and stress-modulating neuropeptide.

4.DELIVERY & SHIPPING

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