[Ala31,Aib32]-Neuropeptide Y (porcine) CAS NO.313988-59-9

[Ala³¹,Aib³²]-Neuropeptide Y (porcine) (CAS NO. 313988-59-9) is a synthetic, engineered analog of porcine neuropeptide Y (NPY). This research-grade peptide incorporates two strategic modifications: an alanine at position 31 and the non-natural, helix-stabilizing amino acid α-aminoisobutyric acid (Aib) at position 32. These alterations are designed to enhance the peptide's metabolic stability and receptor selectivity, making it a valuable tool for investigating NPY receptor pharmacology and the structural basis of ligand-receptor interactions.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Ala³¹,Aib³²]-Neuropeptide Y (porcine)
CAS NO.	313988-59-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C187H281N55O56
Molecular Weight	4194.63/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & dimethyl sulfoxide
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent and selective agonist for Y2 neuropeptide Y receptors
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog acts as a potent agonist for NPY receptors, with its selectivity profile influenced by the specific substitutions. The Aib residue at position 32 introduces a conformational constraint that stabilizes the α-helical structure in the C-terminal region, which is critical for receptor binding. This enhanced structural stability can improve binding affinity and increase resistance to proteolytic degradation.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in peptide chemistry, neuropharmacology, and metabolic studies. Key applications include: studying the impact of α-helix stabilization and unnatural amino acids on peptide stability and receptor selectivity, investigating the structural determinants of NPY binding to its various receptors (Y1, Y2, Y4, Y5), serving as a stabilized agonist in long-duration functional assays, and as a prototype for the design of novel, degradation-resistant NPY receptor ligands with potential therapeutic applications.

3.CLINICAL EFFICACY OF PRODUCT

[Ala³¹,Aib³²]-NPY (porcine) is a research compound, not a clinical therapeutic. Its efficacy lies in its role as a molecular tool for peptide engineering and receptor studies. Research utilizing such analogs provides critical insights into how structural modifications affect a peptide's pharmacological profile—its potency, stability, and receptor preference.

4.DELIVERY & SHIPPING

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