[D-Trp32]-Neuropeptide Y (human)

[D-Trp³²]-Neuropeptide Y (human) is a metabolically stabilized analog of human Neuropeptide Y featuring a D-tryptophan substitution at position 32, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide retains high affinity for NPY receptors (Y1, Y2, Y4, Y5) while exhibiting enhanced proteolytic resistance, making it ideal for prolonged receptor stimulation studies in appetite regulation, energy homeostasis, anxiety, cardiovascular function, and metabolic disorders. It serves as a standardized tool for both in vitroand in vivoinvestigations requiring sustained NPY signaling.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Trp32]-Neuropeptide Y (human)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C196H288N56O56S
Molecular Weight	4356.9 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid (e.g., 0.1% v/v), or phosphate-buffered saline (PBS). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution, then dilute with the desired assay buffer.
Endotoxin	< 1.0 EU/mg
Biological Activity	This analog is a modified version of human Neuropeptide Y with a D-Tryptophan substitution at position 32. This modification is designed to enhance metabolic stability against proteolytic degradation while maintaining affinity for NPY receptors (primarily Y1, Y2, Y4, Y5, Y6). It acts as an agonist, inhibiting adenylate cyclase via Gi/o coupling. Bioactivity should be validated in relevant NPY receptor binding or functional assays (e.g., cAMP inhibition).
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[D-Trp³²]-Neuropeptide Y functions as a potent NPY receptor agonist, binding with high affinity to Y1, Y2, Y4, and Y5 receptor subtypes to couple with Gi/o proteins, thereby inhibiting adenylate cyclase and reducing intracellular cAMP levels. This signaling cascade modulates potassium channel activity, calcium mobilization, and MAPK pathways, leading to altered neuronal excitability, neurotransmitter release, and downstream physiological effects. The D-Trp³² substitution enhances metabolic stability without compromising receptor recognition, resulting in prolonged anorexigenic, anxiolytic, and cardiovascular modulatory actions in central and peripheral systems.

2.PRODUCT INDICATIONS

This modified NPY analog is indicated exclusively for research applications focused on human Neuropeptide Y signaling with extended duration of action. It is employed in NPY receptor binding assays, functional studies measuring cAMP inhibition, appetite and feeding behavior research, anxiety and stress response models, cardiovascular physiology investigations, and metabolic disorder studies. The product serves as a reference agonist for validating NPY receptor expression, screening antagonists, and studying prolonged NPY effects in obesity, anxiety disorders, hypertension, and metabolic syndrome. It is not intended for diagnostic, therapeutic, or clinical use.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, [D-Trp³²]-Neuropeptide Y (human) has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of NPY biology with enhanced pharmacokinetic properties and may inform therapeutic strategies targeting NPY receptors for obesity, anxiety, or cardiovascular diseases, its utility remains confined to preclinical research. Any clinical translation would require development of entirely distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.