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[D-Trp32]-Neuropeptide Y (porcine) CAS NO.178861-83-1

[D-Trp³²]-Neuropeptide Y (porcine) (CAS NO. 178861-83-1) is a synthetic, site-specifically modified analog of porcine neuropeptide Y (NPY). This research-grade peptide incorporates a single, strategically placed D-tryptophan residue at position 32, replacing the native L-isomer.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Trp32]-Neuropeptide Y (porcine)
CAS NO.	3178861-83-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C196H288N56O56S
Molecular Weight	4356.9/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in DMSO, water, or dilute acetic acid; may require gentle sonication for full dissolution
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent and selective neuropeptide Y (NPY) Y₅ receptor agonist; exhibits orexigenic activity and inhibits forskolin-stimulated cAMP formation.
Storage Conditions	yophilized powder: Store at -20°C to -80°C for long-term stability
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog functions as a potent agonist for NPY receptors, primarily targeting the Y1, Y2, and Y5 subtypes. The substitution of the native L-tryptophan with its D-isomer at position 32 confers exceptional resistance to enzymatic breakdown by proteases, significantly prolonging its in vitro and in vivo half-life.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in cardiovascular physiology, neuropharmacology, and metabolic disorders where sustained NPY receptor activation is required. Key applications include: investigating long-term effects of NPY signaling in models of hypertension and obesity, studying the role of NPY in stress and anxiety over extended periods, serving as a stable reference agonist in chronic functional assays, and as a key compound in structure-activity relationship (SAR) studies to develop protease-resistant peptide therapeutics.

3.CLINICAL EFFICACY OF PRODUCT

[D-Trp³²]-NPY (porcine) is a specialized research probe, not a clinical drug. Its efficacy is demonstrated in preclinical studies as a robust tool for investigating the consequences of prolonged NPY receptor stimulation. The incorporation of a D-amino acid represents a proven strategy in medicinal chemistry to overcome the rapid degradation of natural peptides.

4.DELIVERY & SHIPPING

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