Neuropeptide Y (2-36) (human, rat) CAS NO.123139-39-9

Neuropeptide Y (2-36) (human, rat) (CAS NO. 123139-39-9) is a synthetic 35-amino acid peptide representing a major N-terminally truncated metabolite of the full-length neuropeptide Y (NPY). This high-purity, research-grade fragment lacks the N-terminal tyrosine residue (position 1) but retains the core structure essential for receptor binding, offering a distinct pharmacological profile. It serves as a critical tool for studying NPY processing and differential receptor activation.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Trp32]-Neuropeptide Y (2-36) (human, rat)
CAS NO.	23139-39-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C180H276N54O55S
Molecular Weight	4108.6/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water, dilute acetic acid, or DMSO; gentle sonication may aid dissolution
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent and selective agonist for neuropeptide Y (NPY) Y₁ and Y₅ receptors; exhibits orexigenic activity and modulates neurotransmission.
Storage Conditions	Lyophilized powder: Store at -20°C to -80°C for long-term stability
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide fragment acts as a selective ligand for NPY receptors, with a markedly altered receptor preference compared to NPY (1-36). The removal of the N-terminal Tyr¹ drastically reduces its affinity for the Y1 receptor subtype. Consequently, NPY (2-36) functions primarily as a high-affinity agonist for the Y2 and Y5 receptors.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in neuropharmacology and metabolism, specifically to dissect subtype-specific NPY receptor functions. Key applications include: studying the selective activation of Y2 and Y5 receptors in appetite regulation and energy homeostasis, investigating presynaptic Y2 receptor-mediated inhibition of neurotransmitter release in various brain regions, exploring the roles of Y2/Y5 receptors in anxiety, stress, and memory, and serving as a reference Y1-sparing agonist in receptor binding and functional assays to characterize novel NPY receptor ligands.

3.CLINICAL EFFICACY OF PRODUCT

Neuropeptide Y (2-36) is a vital research tool, not a direct therapeutic. Its "efficacy" lies in its unique ability to separate Y1 receptor-mediated effects from those of other subtypes. Research utilizing this fragment has been instrumental in delineating the specific physiological roles of Y2 and Y5 receptors. This knowledge is foundational for the targeted development of receptor-subtype-specific drugs.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.