Neuropeptide Y (2-36), amide, porcine CAS NO.102961-52-4

Neuropeptide Y (2-36), amide, porcine is an N-terminally truncated fragment of porcine NPY (residues 2-36) with C-terminal amidation, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide retains high affinity for NPY receptors but exhibits altered receptor selectivity compared to full-length NPY, particularly favoring Y₂ and Y₅ subtypes. It serves as a valuable tool for dissecting NPY receptor subtype-specific signaling, presynaptic inhibition studies, and comparative pharmacology of NPY fragments in appetite regulation, anxiety, and autonomic function research.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide Y (2-36), amide, porcine
CAS NO.	102961-52-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C181H278N54O55
Molecular Weight	4090.6g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid (e.g., 0.1 % v/v), or phosphate-buffered saline (PBS). For best results, first dissolve in a small volume of 0.1 % acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution, then dilute with assay buffer
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide corresponds to the N‑terminally truncated form of porcine NPY (residues 2‑36). It retains high affinity for NPY receptors (primarily Y₂, Y₅, and Y₁ subtypes) and exhibits potent agonist activity, particularly at Y₂ receptors involved in presynaptic inhibition of neurotransmitter release. Bioactivity can be validated in receptor‑binding assays (e.g., competition with radiolabeled NPY) or functional assays measuring cAMP inhibition in Y receptor‑expressing cells
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuropeptide Y (2-36) functions as a potent NPY receptor agonist with preferential binding to Y₂ and Y₅ receptors over Y₁ receptors due to the absence of the N-terminal Tyr¹ residue. Upon receptor binding, it couples with Gi/o proteins to inhibit adenylate cyclase, reduce intracellular cAMP levels, and modulate potassium and calcium channel activity. This signaling cascade leads to presynaptic inhibition of neurotransmitter release (particularly noradrenaline and GABA), decreased neuronal excitability, and physiological effects on feeding behavior, anxiety-like responses, and cardiovascular regulation, providing a selective tool to study Y₂/Y₅-mediated pathways.

2.PRODUCT INDICATIONS

This porcine NPY fragment is indicated exclusively for research applications focused on NPY receptor subtype selectivity and presynaptic modulation studies. It is employed in Y₂/Y₅-selective receptor binding assays, functional studies measuring cAMP inhibition and neurotransmitter release, appetite and feeding behavior research with emphasis on Y₂-mediated effects, anxiety and stress response models, and autonomic nervous system investigations. The product serves as a reference agonist for validating Y₂/Y₅ receptor expression, screening subtype-selective antagonists, and studying the differential roles of NPY receptor subtypes in obesity, anxiety disorders, and cardiovascular regulation. It is not intended for diagnostic, therapeutic, or clinical use.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Neuropeptide Y (2-36), amide, porcine has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of Y₂/Y₅ receptor biology and may inform the development of future therapeutic agents targeting these receptors for obesity, anxiety, or cardiovascular diseases, its utility remains confined to preclinical research. Any clinical translation would require development of entirely distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.