Neuropeptide Y (1-24) amide (human, rat) CAS NO.131448-51-6
Neuropeptide Y (1-24) amide (human, rat) CAS NO.131448-51-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neuropeptide Y (1-24) amide (human, rat) |
| CAS NO. | 131448-51-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₁₆H₁₇₀N₃₀O₄₀S |
| Molecular Weight | 2657.1g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥1 mg/mL), PBS buffer (pH 7.2–7.4), and DMSO; slightly soluble in methanol/ethanol |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Agonist of neuropeptide Y receptors (Y1, Y2, Y4, Y5); modulates appetite, energy metabolism, and cardiovascular function; retains core signaling activity of full-length NPY |
| Storage Conditions | -20°C for long-term storage (stable for 2 years); avoid repeated freeze-thaw cycles; store desiccated |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The biological effects of Neuropeptide Y (1-24) amide are mediated through its high-affinity binding to neuropeptide Y receptors (Y1, Y2, Y4, Y5), a family of G-protein-coupled receptors (GPCRs) widely distributed in the central nervous system, cardiovascular system, and peripheral tissues. Upon receptor binding, it activates downstream G-protein signaling pathways, primarily inhibiting adenylate cyclase activity and reducing intracellular cAMP levels, while also modulating calcium ion channels and mitogen-activated protein kinase (MAPK) pathways.
2.PRODUCT INDICATIONS
Neuroscience research: Investigation of NPY-mediated appetite regulation, energy metabolism, mood, and circadian rhythm pathways in human and rat models.
NPY receptor research: Study of Y1/Y2/Y4/Y5 receptor structure-function relationships, serving as a standard ligand for receptor activation assays and agonist/antagonist screening.
Cardiovascular research: Evaluation of NPY’s role in vascular tone regulation and blood pressure modulation, supporting cardiovascular disease mechanism studies.
3.CLINICAL EFFICACY OF PRODUCT
Neuropeptide Y (1-24) amide (CAS 131448-51-6) is widely used in preclinical research, with proven efficacy in human and rat in vitro and in vivo models. In rodent studies, it has shown significant appetite-stimulating effects via hypothalamic Y1/Y5 receptor activation, providing a reliable tool for studying obesity and energy metabolism disorders.
In cardiovascular models, it effectively induces vasoconstriction and modulates blood pressure, supporting research on NPY-related cardiovascular pathologies. In human cell-based assays, it retains high affinity for NPY receptors, enabling translational research for developing therapeutics targeting NPY pathways. While clinical efficacy in humans is yet to be directly evaluated, its conserved activity across species makes it a critical tool for preclinical studies, aiding the development of drugs for metabolic, neurological, and cardiovascular diseases. Our high-purity product ensures consistent performance for reliable research outcomes.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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