Neuropeptide Y (3-36) (porcine) CAS NO.143863-88-1

Neuropeptide Y (3-36) (porcine) (CAS NO. 143863-88-1) is a synthetic, 34-amino acid peptide representing a key endogenous N-terminally truncated metabolite of porcine neuropeptide Y (NPY). This high-purity research fragment lacks the first two N-terminal amino acids (Tyr¹-Pro²) of full-length NPY, resulting in a significant shift in receptor selectivity. It is an essential tool for studying the specific physiological roles of the neuropeptide Y Y2 receptor.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide Y (3-36) (porcine)
CAS NO.	143863-88-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C176H271N53O54
Molecular Weight	3993.4/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Selective agonist for neuropeptide Y (NPY) Y₁ and Y₅ receptors
Storage Conditions	Lyophilized powder: Store at -20°C to -80°C for long-term stability
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as a potent and selective agonist for the neuropeptide Y Y2 receptor (NPY Y2R). The truncation eliminates its ability to activate the Y1 and Y5 receptor subtypes effectively. Upon binding to the presynaptic Y2 receptor, it activates inhibitory Gi/o proteins, leading to a suppression of adenylate cyclase activity and a decrease in intracellular cyclic AMP (cAMP) levels.

2.PRODUCT INDICATIONS

This product is indicated for precise research in neuropharmacology, metabolism, and cardiovascular science focusing on Y2 receptor-specific pathways. Key applications include: studying the role of presynaptic Y2 receptors in regulating neurotransmitter release and neuronal excitability, investigating Y2-mediated effects on anxiety, stress responses, and memory consolidation, exploring its impact on energy metabolism and fat storage (anti-lipolytic effect), and serving as the definitive selective Y2 receptor agonist in receptor binding and functional assays for drug discovery.

3.CLINICAL EFFICACY OF PRODUCT

Neuropeptide Y (3-36) is a critical research ligand, not a therapeutic agent. Its efficacy is defined by its role as the prototypical selective Y2 receptor agonist. Research using this peptide has been fundamental in validating the Y2 receptor as a major therapeutic target.

4.DELIVERY & SHIPPING

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