english

Neuropeptide Y (3-36) (porcine) CAS NO.143863-88-1

Neuropeptide Y (3-36) (porcine) (CAS NO. 143863-88-1) is a synthetic, 34-amino acid peptide representing a key endogenous N-terminally truncated metabolite of porcine neuropeptide Y (NPY). This high-purity research fragment lacks the first two N-terminal amino acids (Tyr¹-Pro²) of full-length NPY, resulting in a significant shift in receptor selectivity. It is an essential tool for studying the specific physiological roles of the neuropeptide Y Y2 receptor.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide Y (3-36) (porcine)
CAS NO.	143863-88-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C176H271N53O54
Molecular Weight	3993.4/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Selective agonist for neuropeptide Y (NPY) Y₁ and Y₅ receptors
Storage Conditions	Lyophilized powder: Store at -20°C to -80°C for long-term stability
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as a potent and selective agonist for the neuropeptide Y Y2 receptor (NPY Y2R). The truncation eliminates its ability to activate the Y1 and Y5 receptor subtypes effectively. Upon binding to the presynaptic Y2 receptor, it activates inhibitory Gi/o proteins, leading to a suppression of adenylate cyclase activity and a decrease in intracellular cyclic AMP (cAMP) levels.

2.PRODUCT INDICATIONS

This product is indicated for precise research in neuropharmacology, metabolism, and cardiovascular science focusing on Y2 receptor-specific pathways. Key applications include: studying the role of presynaptic Y2 receptors in regulating neurotransmitter release and neuronal excitability, investigating Y2-mediated effects on anxiety, stress responses, and memory consolidation, exploring its impact on energy metabolism and fat storage (anti-lipolytic effect), and serving as the definitive selective Y2 receptor agonist in receptor binding and functional assays for drug discovery.

3.CLINICAL EFFICACY OF PRODUCT

Neuropeptide Y (3-36) is a critical research ligand, not a therapeutic agent. Its efficacy is defined by its role as the prototypical selective Y2 receptor agonist. Research using this peptide has been fundamental in validating the Y2 receptor as a major therapeutic target.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.