Neuropeptide Y (22-36) CAS NO.119019-65-7

Neuropeptide Y (22-36) (CAS 119019-65-7) is a premium bioactive NPY fragment with a defined molecular formula (C₈₅H₁₃₉N₂₉O₂₁) and molecular weight (1903.2 g/mol). As a professional Neuropeptide Y (22-36) supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxin levels, and selective Y2 receptor activity, tailored for neuroscience research and pharmaceutical R&D. It excels as a potent phosphodiesterase inhibitor and neurotransmitter modulator, widely used in anxiety regulation, stress research, and Y2 receptor studies. Choose our product for high-quality support in your receptor-specific research!

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide Y (22-36)
CAS NO.	119019-65-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C₈₅H₁₃₉N₂₉O₂₁
Molecular Weight	1903.2g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water; also soluble in PBS buffer (pH 7.2–7.4); may be dissolved in DMSO or 10%-30% acetic acid if water dissolution is incomplete
Endotoxin	< 1.0 EU/mg
Biological Activity	Selective agonist of Neuropeptide Y Y2 receptors (sub-nanomolar affinity for Y2 receptors); potent inhibitor of calmodulin-stimulated phosphodiesterase (more potent than full-length NPY); modulates presynaptic neurotransmitter release; involved in stress resilience, anxiety regulation, and energy homeostasis
Storage Conditions	-20°C for long-term storage (stable for 3 years as lyophilized powder); -80°C for 1 year when dissolved in solvent; store desiccated, avoid repeated freeze-thaw cycles; ship with blue ice or at ambient temperature (regional variation allowed)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The biological effects of Neuropeptide Y (22-36) are primarily mediated through its high-affinity and selective binding to Neuropeptide Y Y2 receptors, a G-protein-coupled receptor (GPCR) subtype predominantly expressed on presynaptic neurons and peripheral tissues. As a Y2 receptor-specific agonist, it exerts its functions via two core pathways: inhibiting calmodulin-stimulated phosphodiesterase activity and modulating presynaptic neurotransmitter release.

2.PRODUCT INDICATIONS

NPY Y2 receptor research: Investigation of Y2 receptor structure-function relationships, serving as a standard ligand for receptor activation assays, agonist/antagonist screening, and selectivity validation.

Neuroscience research: Study of Y2 receptor-mediated pathways related to stress resilience, anxiety regulation, presynaptic neurotransmission, and energy homeostasis.

Psychopharmacology research: Exploration of Y2 receptor signaling as a potential therapeutic target for anxiety disorders, stress-related illnesses, and mood disorders.

3.CLINICAL EFFICACY OF PRODUCT

Neuropeptide Y (22-36) (CAS 119019-65-7) is widely utilized in preclinical research, with proven efficacy in in vitro and in vivo models focusing on Y2 receptor function. In cell-based assays, it exhibits sub-nanomolar affinity for Y2 receptors and potent phosphodiesterase inhibition, providing a reliable tool for validating Y2 receptor activity and screening targeted compounds.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.