Neuropeptide Y (18-36)

Neuropeptide Y (18-36), human is a C-terminal fragment of human NPY (residues 18-36) with C-terminal amidation, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide retains significant binding to NPY receptors with preferential activity at the Y₂ subtype, serving as a shorter C-terminal tool compared to NPY (13-36) for studying Y₂-mediated signaling. It is used in receptor binding assays, functional studies of presynaptic inhibition, and investigations into feeding behavior, anxiety, and autonomic regulation where Y₂ receptor activation is implicated.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide Y (18-36)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C134H207N41O36S
Molecular Weight	3000.5g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid (e.g., 0.1 % v/v), or phosphate‑buffered saline (PBS). For best results, first dissolve in a small volume of 0.1 % acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide is the C‑terminal fragment (residues 18‑36) of human Neuropeptide Y. It retains binding affinity for NPY receptors, with reported activity primarily at the Y₂ subtype, and is commonly used as a tool to study Y₂‑mediated functions such as presynaptic inhibition and feeding behavior. Activity should be validated in Y₂ receptor binding or functional assays.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuropeptide Y (18-36) functions as a Y₂ receptor-preferring agonist, binding to NPY Y₂ receptors and coupling to Gi/o proteins to inhibit adenylate cyclase and reduce intracellular cAMP levels. This signaling cascade activates inwardly rectifying potassium channels and inhibits voltage-gated calcium channels, leading to presynaptic inhibition of neurotransmitter release (e.g., glutamate, GABA). The resulting hyperpolarization and reduced neuronal excitability modulate synaptic transmission, contributing to effects on feeding behavior, anxiety-like responses, and autonomic nervous system regulation, making it a selective probe for Y₂ receptor-specific pathways.

2.PRODUCT INDICATIONS

This human NPY fragment is indicated exclusively for research applications focused on Y₂ receptor pharmacology and truncated NPY fragment studies. It is employed in Y₂-selective receptor binding and competition assays, functional studies of presynaptic inhibition and neurotransmitter release, appetite and feeding behavior research with emphasis on Y₂-mediated effects, anxiety and stress response models, and autonomic function investigations. The product serves as a reference ligand for validating Y₂ receptor expression, screening Y₂-selective compounds, and comparing the activity of different NPY C-terminal fragments in obesity, anxiety, and cardiovascular research. It is not intended for diagnostic, therapeutic, or clinical use.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Neuropeptide Y (18-36), human has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of Y₂ receptor biology and may inform the development of future therapeutic agents targeting Y₂ receptors for obesity, anxiety, or autonomic disorders, its utility remains confined to preclinical research. Any clinical translation would require development of entirely distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.