[Pro34]-Neuropeptide Y, human, rat; [Pro34]-NPY, human, rat CAS

[Pro³⁴]-Neuropeptide Y, human, rat ([Pro³⁴]-NPY) is a premium modified neuropeptide with a defined molecular formula (C₁₈₉H₂₈₅N₅₅O₅₇S) and molecular weight (4271.8 g/mol). As a professional [Pro³⁴]-NPY supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxin levels, and enhanced stability, tailored for neuroscience research, pharmaceutical R&D, and cross-species studies. It excels as a broad-spectrum NPY receptor agonist and Phosphodiesterase inhibitor peptide, widely used in appetite regulation, cardiovascular research, and signal transduction studies. Choose our [Pro³⁴]-NPY for high-quality, reliable support in your preclinical and translational research!

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Pro34]-Neuropeptide Y, human, rat; [Pro34]-NPY, human, rat CAS
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₈₉H₂₈₅N₅₅O₅₇S
Molecular Weight	4271.8g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS buffer (pH 7.2–7.4), and DMSO (≥2 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of neuropeptide Y receptors (Y1, Y2, Y4, Y5); enhanced stability and prolonged half-life compared to native NPY; modulates appetite, energy metabolism, cardiovascular function, and neuronal excitability; retains cross-species activity in human and rat models
Storage Conditions	-20°C for long-term storage (stable for 2 years as lyophilized powder)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Pro³⁴]-NPY exerts its biological effects through a dual mechanism, combining broad-spectrum NPY receptor activation and Phosphodiesterase inhibitor peptide activity. The Pro³⁴ substitution optimizes the peptide’s conformational stability, enhancing its binding affinity to all NPY receptor subtypes (Y1, Y2, Y4, Y5)—G-protein-coupled receptors (GPCRs) widely distributed in the central nervous system, cardiovascular tissues, and peripheral organs. Upon receptor binding, it activates Gi/o protein signaling pathways, inhibiting adenylate cyclase to reduce intracellular cyclic adenosine monophosphate (cAMP) levels and modulating calcium ion channels to regulate cellular excitability.

2.PRODUCT INDICATIONS

NPY receptor research: Investigation of Y1/Y2/Y4/Y5 receptor structure-function relationships, serving as a standard ligand for activation assays, agonist/antagonist screening, and stability validation in cross-species studies.

Neuroscience research: Study of NPY-mediated pathways in appetite regulation, anxiety, stress response, and neuronal excitability, leveraging its Phosphodiesterase inhibitor peptide property to dissect cAMP-related signaling.

Cardiovascular research: Evaluation of NPY-induced vasoconstriction and blood pressure modulation, supporting studies on cardiovascular pathologies linked to NPY signaling and phosphodiesterase activity.

3.CLINICAL EFFICACY OF PRODUCT

[Pro³⁴]-NPY is widely utilized in preclinical research, with proven efficacy in human and rat in vitro and in vivo models. As a Phosphodiesterase inhibitor peptide, it exhibits stronger inhibitory activity against calmodulin-stimulated phosphodiesterase than native NPY, providing a reliable tool for dissecting cAMP-related signaling pathways in neuronal, cardiovascular, and metabolic cells.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.