Ac-[Leu28,31]-Neuropeptide Y (24-36) CAS NO.155709-24-3

Ac-[Leu²⁸,³¹]-Neuropeptide Y (24-36) (CAS NO. 155709-24-3) is a synthetic, stabilized, and acetylated peptide fragment derived from the C-terminal region of neuropeptide Y (NPY). This research-grade analog incorporates two leucine substitutions (at positions 28 and 31) and an N-terminal acetylation, modifications designed to enhance its receptor binding affinity, selectivity, and metabolic stability.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ac-[Leu28,31]-Neuropeptide Y (24-36)
CAS NO.	155709-24-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C81H131N27O19
Molecular Weight	1787.1/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute acetic acid, or DMSO; gentle sonication may aid full dissolution
Endotoxin	≤1.0 EU/mg
Biological Activity	Selective agonist for neuropeptide Y (NPY) Y₅ receptors
Storage Conditions	Lyophilized powder: Store at -20°C to -80°C for long-term stability.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This engineered peptide acts as a potent and selective agonist for the neuropeptide Y Y2 receptor (NPY Y2R). The leucine substitutions at positions 28 and 31 are strategically placed within the receptor-binding domain to optimize interaction with the Y2 receptor pocket, enhancing selectivity over other NPY receptor subtypes. The N-terminal acetylation further increases its stability against enzymatic degradation.

2.PRODUCT INDICATIONS

This product is indicated for high-precision research in neuropharmacology and receptor biology. Key applications include: as a selective Y2 receptor agonist in studies of presynaptic inhibition, anxiety, and memory; for investigating the structure-activity relationship (SAR) of NPY analogs at the Y2 receptor; as a stable tool compound in long-duration functional assays; and in the development and screening of novel Y2 receptor-targeted therapeutics for conditions like obesity, anxiety, and epilepsy.

3.CLINICAL EFFICACY OF PRODUCT

Ac-[Leu²⁸,³¹]-NPY (24-36) is a sophisticated research probe, not a clinical therapeutic. Its "efficacy" lies in its optimized design as a selective and stable Y2 receptor ligand. Research using such engineered fragments provides critical insights into the pharmacophore required for Y2 receptor activation.

4.DELIVERY & SHIPPING

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