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[Thr³⁰]-Neuropeptide Y, human; [Thr³⁰]-NPY, human

[Thr³⁰]-Neuropeptide Y, human ([Thr³⁰]-NPY, human) is a premium modified human neuropeptide with a defined molecular formula (C₁₈₇H₂₈₀N₅₄O₅₉S) and molecular weight (4259.7 g/mol). As a professional [Thr³⁰]-NPY supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxin levels, and enhanced stability, tailored for human-focused neuroscience research and pharmaceutical R&D. It excels as a broad-spectrum NPY receptor agonist, widely used in appetite regulation studies, cardiovascular research, and peptide modification assays. Choose our [Thr³⁰]-NPY for high-quality, reliable support in your human-centric preclinical research!

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Thr³⁰]-Neuropeptide Y, human; [Thr³⁰]-NPY, human
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₈₇H₂₈₀N₅₄O₅₉S
Molecular Weight	4259.7g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS buffer (pH 7.2–7.4), and DMSO (≥2 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of neuropeptide Y receptors (Y1, Y2, Y4, Y5); enhanced stability and prolonged half-life compared to native human NPY; modulates appetite, energy metabolism, cardiovascular function, and neuronal excitability; retains high receptor binding affinity in human models
Storage Conditions	-20°C for long-term storage (stable for 2 years as lyophilized powder)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Thr³⁰]-Neuropeptide Y, human exerts its biological effects primarily through high-affinity binding to all subtypes of neuropeptide Y receptors (Y1, Y2, Y4, Y5)—G-protein-coupled receptors (GPCRs) widely expressed in the human central nervous system, cardiovascular tissues, and peripheral organs. The Thr³⁰ substitution optimizes the peptide’s conformational structure, enhancing its resistance to enzymatic degradation and prolonging its in vitro and in vivo half-life without compromising receptor binding affinity.

2.PRODUCT INDICATIONS

Human NPY receptor research: Investigation of Y1/Y2/Y4/Y5 receptor structure-function relationships in human systems, serving as a standard ligand for activation assays, agonist/antagonist screening, and stability validation.

Human neuroscience research: Study of NPY-mediated pathways in appetite regulation, anxiety, stress response, and neuronal excitability, leveraging the peptide’s enhanced stability for long-term assays.

Cardiovascular research: Evaluation of NPY-induced vasoconstriction and blood pressure modulation in human cardiovascular models, supporting studies on NPY-related cardiovascular pathologies.

3.CLINICAL EFFICACY OF PRODUCT

[Thr³⁰]-Neuropeptide Y, human is widely utilized in preclinical human-focused research, with proven efficacy in human in vitro cell models and translational animal studies. In human neuronal and cardiovascular cell assays, it exhibits sustained receptor activation and biological activity, outperforming native NPY due to its enhanced stability—providing reliable data for translational research.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.