[D-Tyr²⁷,³⁶, D-Thr³²]-Neuropeptide Y (27-36),rat rat CAS NO.163887-48-7

[D-Tyr²⁷,³⁶, D-Thr³²]-Neuropeptide Y (27-36), rat (CAS 163887-48-7) is a premium modified NPY fragment with molecular formula C₆₁H₉₉N₁₉O₁₅ and molecular weight 1338.6 g/mol. As a professional supplier, we deliver this product with ≥98% purity, low endotoxins, and enhanced stability, tailored for rat research and pharmaceutical R&D. It excels as a selective Y1 receptor agonist and Human metabolic research peptide, widely used in appetite regulation, metabolic studies, and translational research. Choose our product for high-quality support in your rat-focused preclinical projects!

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Tyr²⁷,³⁶, D-Thr³²]-Neuropeptide Y (27-36), rat
CAS NO.	163887-48-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C₆₁H₉₉N₁₉O₁₅
Molecular Weight	1338.6g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS buffer (pH 7.2–7.4), and DMSO (≥2 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Selective agonist of neuropeptide Y Y1 receptors; enhanced stability and resistance to enzymatic degradation compared to native rat NPY fragments; modulates appetite and energy metabolism in rat models; exhibits potent activity as a Human metabolic research peptide tool for translational studies
Storage Conditions	-20°C for long-term storage (stable for 2 years as lyophilized powder)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The biological effects of [D-Tyr²⁷,³⁶, D-Thr³²]-NPY (27-36), rat are mediated through high-affinity and selective binding to neuropeptide Y Y1 receptors—G-protein-coupled receptors (GPCRs) expressed in the rat hypothalamus, vascular smooth muscle, and peripheral metabolic tissues. The D-amino acid substitutions (D-Tyr²⁷,³⁶ and D-Thr³²) alter the peptide’s conformational structure, significantly improving resistance to endogenous peptidases and prolonging its half-life in rat in vitro and in vivo models, compared to native NPY fragments.

2.PRODUCT INDICATIONS

NPY Y1 receptor research: Investigation of Y1 receptor structure-function relationships in rat models, serving as a standard ligand for activation assays, agonist/antagonist screening, and selectivity validation.

Metabolic research: Utilization as a Human metabolic research peptide to study Y1 receptor-mediated appetite regulation, energy metabolism, and obesity-related pathways in rat models for translational applications

Neuroscience research: Study of Y1 receptor signaling in the rat hypothalamus, focusing on stress response, anxiety, and neuronal excitability linked to metabolic regulation.

3.CLINICAL EFFICACY OF PRODUCT

[D-Tyr²⁷,³⁶, D-Thr³²]-NPY (27-36), rat (CAS 163887-48-7) is widely used in preclinical rat models, with proven efficacy as a Human metabolic research peptide. In rat hypothalamic cell assays and in vivo studies, it exhibits potent and selective Y1 receptor activation, effectively modulating appetite and energy metabolism with sustained activity due to its enhanced stability—outperforming native NPY fragments.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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