Activity-Dependent Neurotrophic Factor-14 CAS NO.177159-38-5

Activity-Dependent Neurotrophic Factor-14 (ADNF-14) (CAS NO. 177159-38-5) is a synthetic 14-amino acid peptide derived from the activity-dependent neurotrophic factor (ADNF) protein. This research-grade peptide is a potent, active neuroprotective fragment. It is designed to mimic the protective effects of the parent protein and serves as a crucial tool for studying neuronal survival, synaptic plasticity, and mechanisms of neuroprotection in the central nervous system.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Activity-Dependent Neurotrophic Factor-14 (ADNF-14)
CAS NO.	177159-38-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C58H103N17O17
Molecular Weight	1310.57/mol
Purity (RP-HPLC)	≥98%
Solubility	Highly soluble in deionized water and phosphate-buffered saline
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent neurotrophic and neuroprotective peptide.
Storage Conditions	Lyophilized powder: Long-term storage at -20°C to -80°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

ADNF-14 exerts its neuroprotective effects through a receptor-mediated mechanism, though its specific high-affinity receptor is still under characterization. It is known to interact with cell surface binding sites, triggering intracellular signaling cascades that promote neuronal survival. Its action is highly dependent on neuronal activity ("activity-dependent").

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in neuroscience, neuropharmacology, and neurotoxicology. Key applications include: studying mechanisms of neuroprotection against excitotoxicity, oxidative stress, and β-amyloid toxicity; investigating synaptic plasticity, learning, and memory processes; exploring potential therapeutic strategies for neurodegenerative diseases such as Alzheimer's disease; and as a positive control in assays for neuronal survival and viability.

3.CLINICAL EFFICACY OF PRODUCT

ADNF-14 is a preclinical research peptide and not an approved drug. Its "efficacy" is demonstrated in experimental models of neurodegeneration and injury. Studies have shown that ADNF-14 can protect neurons from death induced by various toxins and pathological conditions in cell culture and animal models.

4.DELIVERY & SHIPPING

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