Activity-Dependent Neurotrophic Factor (ADNF)

Activity-Dependent Neurotrophic Factor (ADNF) is a premium endogenous peptide with a defined molecular formula (C₄₁H₇₄N₁₂O₁₂) and molecular weight (927.12 g/mol). As a professional ADNF supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxin levels, and dual activity as a neuroprotective agent and weak NPY Y1 receptor agonist. Tailored for neuroscience research and translational studies, it excels in neurotrophic, neuroprotective, and metabolic-neurotrophic cross-talk assays. Choose our ADNF for high-quality support in your neurobiology and pathway research!

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Activity-Dependent Neurotrophic Factor (ADNF)
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₄₁H₇₄N₁₂O₁₂
Molecular Weight	927.12g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥2 mg/mL), PBS buffer (pH 7.2–7.4), and DMSO (≥1 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent neuroprotective and neurotrophic peptide; supports neuronal survival, differentiation, and synaptic plasticity; modulates glutamate receptor activity to reduce excitotoxicity; cross-reacts as a weak NPY Y1 receptor agonist in rodent models, with secondary effects on metabolic regulation
Storage Conditions	-20°C for long-term storage (stable for 2 years as lyophilized powder)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

ADNF exerts dual biological effects through distinct mechanisms: core neurotrophic/neuroprotective activity and secondary NPY Y1 receptor agonist action. Its primary mechanism involves modulating glutamate receptor activity to reduce excitotoxicity—an important pathway in neuronal damage prevention. By regulating glutamate signaling, ADNF stabilizes neuronal membranes, enhances synaptic plasticity, and promotes the survival and differentiation of neurons in the central and peripheral nervous systems.

2.PRODUCT INDICATIONS

Neuroscience research: Investigation of neurotrophic and neuroprotective pathways, including neuronal survival, differentiation, and synaptic plasticity in neurodegenerative disease models.

NPY Y1 receptor research: Study of weak agonist effects on Y1 receptors, serving as a tool to explore cross-talk between neurotrophic and metabolic signaling pathways.

Neurodegenerative disease research: Evaluation of ADNF’s potential in mitigating excitotoxicity-related neuronal damage in models of Alzheimer’s, Parkinson’s, and stroke.

3.CLINICAL EFFICACY OF PRODUCT

ADNF is widely utilized in preclinical neuroscience research, with proven efficacy in in vitro and in vivo models of neuronal damage and neurotrophy. In neuronal cell cultures, it significantly enhances survival rates and reduces excitotoxicity induced by glutamate overstimulation, validating its neuroprotective potential. As a weak NPY Y1 receptor agonist, it exhibits mild metabolic modulation effects in rodent models, providing valuable insights into the interplay between neurotrophic factors and metabolic signaling.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.