Obestatin, human CAS NO.1081110-72-6
Obestatin, human CAS NO.1081110-72-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Obestatin, human |
| CAS NO. | 1081110-72-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C16H176N32O33 |
| Molecular Weight | 2546.89 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Obestatin is a peptide hormone derived from the ghrelin gene, initially reported to oppose ghrelin's effects on food intake and gastric motility, primarily through binding to the GPR39 receptor. It is involved in regulating appetite, energy balance, and gastrointestinal functions. Bioactivity can be validated in in vitrocell‑based assays (e.g., cAMP accumulation or calcium flux in GPR39‑expressing cells) or in vivofeeding models. |
| Storage Conditions | Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Obestatin functions by binding to the G protein-coupled receptor GPR39, activating signaling pathways that involve Gq/11 proteins, leading to increased intracellular calcium mobilization and activation of phospholipase C. This signaling cascade results in the inhibition of food intake, suppression of gastric emptying, and modulation of insulin secretion and glucose metabolism. Unlike ghrelin, which stimulates appetite, obestatin exerts anorexigenic effects by opposing ghrelin's actions on hypothalamic neurons and gastrointestinal function. The peptide's amidated C-terminus is critical for receptor binding and biological activity, contributing to its stability and efficacy in experimental systems.
2.PRODUCT INDICATIONS
Obestatin, human is indicated exclusively for research applications focused on appetite regulation, energy balance, and metabolic function. It is employed in in vitrostudies using cell lines expressing GPR39 to assess calcium flux, cAMP accumulation, and other signaling pathways. The peptide is also used in in vivomodels to investigate feeding behavior, body weight regulation, gastric motility, and glucose homeostasis. Additionally, it serves as a reference standard in receptor binding assays, autoradiography, and immunohistochemistry to localize obestatin binding sites in tissues. The product is not intended for diagnostic, therapeutic, or clinical use and is strictly for research purposes.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, Obestatin, human has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to the fundamental understanding of appetite regulation and metabolic disorders and may inform the development of future therapeutic strategies targeting the ghrelin-obestatin axis, its utility remains confined to preclinical research. Any clinical translation would require the development of distinct therapeutic agents with comprehensive preclinical and clinical testing.
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