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Orexin B, human CAS NO.205640-91-1

Orexin B, human (CAS NO. 205640-91-1) is a high-purity synthetic peptide used in neuroscience and metabolic research.It serves as a key research tool for studying sleep-wake regulation, appetite, and energy homeostasis.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Orexin B, human
CAS NO.	205640‑91‑1
Appearance	White to off-white lyophilized powder
Molecular Formula	C123H212N44O35S
Molecular Weight	2899.4g/mol
Purity (RP-HPLC)	≥95.0% (can be customized to ≥98.0%)
Solubility	Soluble in water, 0.1 M acetic acid, or PBS (pH 7.0‑7.4)
Endotoxin	< 1.0 EU/mg
Biological Activity	Neuropeptide that activates orexin receptors (OX₁R and OX₂R); regulates sleep/wake cycles, appetite, energy homeostasis, and neuroendocrine functions.
Storage Conditions	Store at –20 °C (lyophilized) or –80 °C (solution). Protect from light and repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1mg

1.MECHANISM OF ACTION

Orexin B, human functions by binding to and activating orexin receptors (OX1R and OX2R) in the brain, stimulating intracellular signaling pathways that promote wakefulness, appetite, and metabolic activity. This interaction helps regulate the balance between sleep and arousal, as well as energy expenditure.

2.PRODUCT INDICATIONS

This peptide is used in preclinical studies of narcolepsy, insomnia, obesity, and metabolic disorders. It is also applied in drug-discovery assays targeting orexin receptors and in models investigating the neural circuits that control sleep, feeding behavior, and energy balance.

3.CLINICAL EFFICACY OF PRODUCT

Early-phase clinical trials suggest that orexin-based therapies can improve wakefulness and reduce excessive daytime sleepiness in patients with sleep disorders. While further research is needed, Orexin B, human provides a valuable pharmacological tool for developing novel treatments aimed at restoring normal sleep-wake patterns and metabolic function.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.