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Orexin B, canine

Orexin B (canine) is a synthetic peptide representing the canine isoform of orexin B (also known as hypocretin 2). This high-purity, 28-amino acid neuropeptide is co-expressed with orexin A from the same precursor protein. It serves as a specific endogenous agonist for orexin receptors (OX1R and OX2R) and is a crucial research tool for studying sleep-wake regulation, energy homeostasis, and neurophysiology in canine models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Orexin B, canine
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C125H214N44O34S
Molecular Weight	2909.44/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in deionized water, phosphate-buffered saline
Endotoxin	≤1.0 EU/mg
Biological Activity	Endogenous canine orexin receptor (OX₁/OX₂) dual agonist with high affinity for both receptors
Storage Conditions	Lyophilized powder: Long-term storage at -20°C to -80°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Orexin B exerts its effects by binding to and activating two G protein-coupled receptors, orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R). It has a higher binding affinity for OX2R and is a potent, equipotent agonist for both receptors. Upon receptor activation, it primarily triggers Gq-mediated signaling, leading to phospholipase C (PLC) activation, inositol trisphosphate (IP₃) production, and intracellular calcium mobilization.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research using canine systems, as well as for comparative neurobiological studies. Key applications include: investigating the specific roles of OX2R and dual orexin receptor signaling in sleep/wake disorders and narcolepsy in dogs, studying energy balance and metabolic regulation, exploring cardiovascular and autonomic control, and serving as a species-specific reference agonist in receptor binding and functional assays (e.g., calcium flux) for orexin receptor pharmacology.

3.CLINICAL EFFICACY OF PRODUCT

Orexin B (canine) is a research-grade peptide, not a veterinary therapeutic. Its efficacy is demonstrated in its critical role in foundational research. Studies in dogs using this peptide have been instrumental in understanding the orexin system's role in maintaining wakefulness, as canine narcolepsy is a naturally occurring model linked to orexin pathway dysfunction.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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