Biotin-Obestatin (human)
Biotin-Obestatin (human)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-Obestatin (human) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C126H190N34O35 |
| Molecular Weight | 2773.19g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This biotin‑conjugated obestatin analog retains binding affinity for the GPR39 receptor and is used primarily as a detection or capture probe. The biotin tag enables high‑affinity binding to streptavidin/avidin conjugates for applications such as receptor pull‑down, immunohistochemistry, flow cytometry, and ELISA. Bioactivity (receptor binding) should be validated in competitive binding assays with native obestatin. |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Biotin-Obestatin (human) binds to the GPR39 receptor with affinity comparable to native obestatin, engaging Gq/11-coupled signaling pathways that lead to intracellular calcium mobilization and phospholipase C activation. The biotin moiety, attached via a flexible linker, minimizes steric hindrance to receptor interaction while providing a stable handle for streptavidin-based detection. This conjugate does not significantly alter the anorexigenic signaling profile of obestatin but is primarily utilized as a detection tool rather than a functional agonist, enabling researchers to study receptor localization, internalization, and binding kinetics without radiolabels.
2.PRODUCT INDICATIONS
This biotinylated conjugate is indicated for research applications focused on obestatin receptor biology, appetite regulation, and metabolic disorders. It is employed in in vitroassays such as streptavidin-based pull-down to isolate GPR39 complexes, immunohistochemistry and immunofluorescence to map receptor distribution in tissues, flow cytometry for cell surface receptor detection, and ELISA or Western blot for obestatin quantification. The product is also used in autoradiography and microscopy studies to visualize binding sites and receptor trafficking, contributing to the understanding of ghrelin-obestatin axis dynamics in metabolic and gastrointestinal research.
3.CLINICAL EFFICACY OF PRODUCT
Biotin-Obestatin (human) has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The conjugate has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use. Its utility is confined to experimental studies of obestatin receptor biology and related pathways, with any potential clinical translation requiring the development of distinct diagnostic or therapeutic agents subject to comprehensive preclinical and clinical validation.
4.DELIVERY & SHIPPING
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