Orexin A, bovine, human, mouse, rat CAS NO.205640-90-0

Orexin A (bovine, human, mouse, rat) (CAS 205640-90-0) is a premium cross-species neuropeptide with a defined molecular formula (C₁₅₂H₂₄₃N₄₇O₄₄S₄) and molecular weight (3561.19 g/mol). As a professional Orexin A supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxin levels, and intact disulfide bonds, ensuring stable OX₁R/OX₂R agonist activity across species. Tailored for neuroscience, sleep research, and metabolic studies, it excels in cross-species translational assays and receptor-specific research. Choose our Orexin A for high-quality support in your preclinical and translational research projects!

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Orexin A, bovine, human, mouse, rat
CAS NO.	205640-90-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₅₂H₂₄₃N₄₇O₄₄S₄
Molecular Weight	3561.19g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS buffer (pH 7.2–7.4, ≥2 mg/mL), and DMSO (≥1.5 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of orexin receptors (OX₁R, OX₂R); regulates wakefulness, sleep-wake cycles, appetite, energy metabolism, and reward pathways; cross-species activity in bovine, human, mouse, rat models; modulates neuronal excitability and neurotransmitter release in the central nervous system
Storage Conditions	-20°C for long-term storage (stable for 2 years as lyophilized powder)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Orexin A exerts its biological effects through high-affinity binding to two G-protein-coupled receptors (GPCRs): orexin receptor 1 (OX₁R) and orexin receptor 2 (OX₂R), which are widely distributed in the central nervous system, particularly in brain regions associated with sleep regulation, appetite control, and reward processing. The conserved sequence and intact disulfide bonds of Orexin A ensure stable binding to these receptors across bovine, human, mouse, and rat species.

2.PRODUCT INDICATIONS

Sleep-wake research: Investigation of OX₁R/OX₂R-mediated sleep regulation pathways, serving as a standard ligand for studying sleep disorders (e.g., narcolepsy) in mouse, rat, and translational human models.

Neuroscience research: Study of neuronal excitability, neurotransmitter release, and reward pathway modulation across bovine, human, mouse, and rat species.

Metabolic research: Evaluation of Orexin A’s role in appetite stimulation and energy metabolism regulation, supporting studies on obesity and metabolic syndrome.

3.CLINICAL EFFICACY OF PRODUCT

Orexin A (CAS 205640-90-0) is widely utilized in preclinical research, with proven efficacy across bovine, human, mouse, and rat in vitro and in vivo models. In mouse and rat sleep disorder models, it effectively modulates sleep-wake cycles by activating OX₂R, reversing sleep fragmentation and promoting wakefulness—providing valuable insights into narcolepsy and insomnia pathologies.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.