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Urocortin III, mouse CAS NO.357952-10-4

Urocortin III, mouse (Ucn III, mouse) (CAS 357952-10-4) is a premium mouse-specific peptide with a defined molecular formula (C₁₈₆H₃₁₂N₅₂O₅₂S₂) and molecular weight (4173.01 g/mol). As a professional Urocortin III supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxin levels, and intact structural integrity, ensuring selective CRF₂R agonist activity. Tailored for mouse-focused neuroscience, stress physiology, and cardiovascular research, it excels in CRF₂R-specific assays and preclinical studies. Choose our Urocortin III, mouse for high-quality support in your mouse model research and translational projects!

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Urocortin III, mouse; Ucn III, mouse
CAS NO.	357952-10-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₈₆H₃₁₂N₅₂O₅₂S₂
Molecular Weight	4173.01 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS buffer (pH 7.2–7.4, ≥2 mg/mL), and DMSO (≥1.5 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of corticotropin-releasing factor receptor 2 (CRF₂R); exhibits high selectivity for CRF₂R over CRF₁R; regulates stress response, anxiety-like behaviors, cardiovascular function, and energy metabolism in mouse models; modulates neuronal excitability and inflammatory responses
Storage Conditions	-20°C for long-term storage (stable for 2 years as lyophilized powder)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The biological effects of Urocortin III, mouse are mediated through high-affinity and selective binding to corticotropin-releasing factor receptor 2 (CRF₂R), a G-protein-coupled receptor (GPCR) predominantly expressed in the mouse central nervous system (hypothalamus, amygdala), cardiovascular tissues, and peripheral organs involved in stress and metabolic regulation. The peptide’s disulfide bond and mouse-specific sequence ensure optimal conformational structure for CRF₂R binding, avoiding off-target activation of CRF₁R.

2.PRODUCT INDICATIONS

CRF₂R research: Investigation of CRF₂R structure-function relationships in mouse models, serving as a standard ligand for receptor activation assays, agonist/antagonist screening, and selectivity validation.

Stress physiology research: Study of CRF₂R-mediated stress response and anxiety-like behaviors in mice, supporting the exploration of stress-related neurological disorders.

Cardiovascular research: Evaluation of Urocortin III’s role in regulating mouse cardiovascular function, including vasodilation and cardiac contractility, for cardiovascular pathology studies.

3.CLINICAL EFFICACY OF PRODUCT

Urocortin III, mouse (CAS 357952-10-4) is widely utilized in mouse-focused preclinical research, with proven efficacy in both in vitro and in vivo models. In mouse neuronal cell assays, it exhibits potent and selective CRF₂R activation, effectively modulating stress-related signaling pathways without CRF₁R interference, ensuring precise research outcomes.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.