Urocortin, rat CAS NO.171543-83-2

Urocortin (rat) is a synthetic, 40-amino acid neuropeptide representing the endogenous rat isoform. As a high-purity research reagent, it is a key member of the corticotropin-releasing factor (CRF) family. It binds with high affinity to both CRF1 and CRF2 receptors, with a strong preference for CRF2, and serves as an essential tool for investigating stress biology, cardiovascular regulation, and metabolic functions in rodent models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Urocortin, rat
CAS NO.	171543-83-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C206H338N62O64
Molecular Weight	4707.37/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in deionized water, dilute acetic acid (0.1% v/v), and DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	A conserved invertebrate neuropeptide homologous to vertebrate NPY
Storage Conditions	Lyophilized powder: Store at -20°C to -80°C for long-term stability.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide exerts its biological effects by selectively activating corticotropin-releasing factor receptors, primarily the CRF2 subtype. Upon binding, it triggers Gs protein-mediated signaling, leading to stimulation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels. This signaling pathway modulates diverse physiological responses: in the central nervous system, it can produce anxiolytic-like effects and suppress appetite; in the cardiovascular system, it induces potent vasodilation and positive inotropic effects (increased heart contractility); and it also influences the hypothalamic-pituitary-adrenal (HPA) axis activity.

2.PRODUCT INDICATIONS

This product is indicated for preclinical research using rat models in neuroscience, cardiovascular physiology, and endocrinology. Key applications include: studying the role of the CRF2 receptor in stress adaptation, anxiety, and depression-like behaviors; investigating the cardioprotective and hemodynamic effects of urocortin in models of heart failure and ischemia; exploring its anorexigenic (appetite-suppressing) effects and role in energy balance; and serving as a species-specific reference agonist in receptor binding and functional assays targeting the CRF system.

3.CLINICAL EFFICACY OF PRODUCT

Urocortin (rat) is a research tool, not a direct human therapeutic. Its "efficacy" is demonstrated in robust preclinical rodent models, which have been instrumental in validating its therapeutic potential. Studies in rats have shown that urocortin can improve cardiac function in heart failure, reduce anxiety-like behaviors, and decrease food intake.

4.DELIVERY & SHIPPING

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