[Tyr0]-Urocortin (rat) CAS NO.187111-93-9

[Tyr0]-Urocortin (rat) CAS NO.187111-93-9

[Tyr⁰]-Urocortin (rat) (CAS NO. 187111-93-9) is a high‑purity synthetic peptide engineered for advanced neuroendocrine and stress‑response research.It is a modified urocortin analogue designed to explore CRF‑receptor signaling and related physiological pathways.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Tyr⁰]-Urocortin (rat)
CAS NO.	187111-93-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C215H347N63O66
Molecular Weight	4870.55g/mol
Purity (RP-HPLC)	≥95.0% (can be customized to ≥98.0%)
Solubility	Soluble in water, 0.1 M acetic acid, or PBS (pH 7.0‑7.4)
Endotoxin	< 1.0 EU/mg
Biological Activity	Modified Urocortin analogue with an N‑terminal tyrosine; binds to corticotropin‑releasing factor receptors (CRF₁R/CRF₂R) and modulates stress response, anxiety, and appetite regulation.
Storage Conditions	Store at –20 °C, protected from light and moisture. For long‑term storage, recommend –80 °C.
Stock Location	Stock in USA
MOQ	1mg

1.MECHANISM OF ACTION

This peptide functions as a selective agonist for corticotropin‑releasing factor receptors (CRF₁R and CRF₂R), activating intracellular signaling cascades that modulate stress adaptation, energy expenditure, and autonomic nervous system activity. Its N‑terminal tyrosine modification enhances receptor interaction and stability in experimental settings.

2.PRODUCT INDICATIONS

[Tyr⁰]-Urocortin (rat) is used in preclinical studies of stress‑related disorders, anxiety, metabolic syndrome, and cardiovascular dysregulation. It also serves as a key reagent in drug‑discovery screens targeting CRF receptors and in research investigating the neuroendocrine control of appetite and energy balance.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical data demonstrate that this analogue can attenuate stress‑induced behavioral and physiological responses, improve metabolic parameters, and reduce inflammatory markers in rodent models. While not yet in clinical use, it provides a robust pharmacological tool for validating CRF‑receptor pathways and supporting the development of novel therapeutics for stress‑ and metabolism‑linked conditions.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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