[Lys8,Asn9] Neurotensin LANT-6 (8-13)

[Lys⁸,Asn⁹] Neurotensin LANT-6 (8-13) is a synthetic, modified hexapeptide analog derived from the potent active core of neurotensin (NT). This research-grade peptide incorporates specific amino acid substitutions (lysine at position 8 and asparagine at position 9) within the LANT-6 sequence. These modifications are designed to systematically alter its receptor binding profile, selectivity, and potentially its metabolic stability compared to the native neurotensin (8-13) fragment, making it a specialized tool for studying neurotensin receptor pharmacology.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Lys⁸,Asn⁹] Neurotensin LANT-6 (8-13)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C36H58N8O9
Molecular Weight	746.91/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water (up to 5 mg/mL), dilute acetic acid, DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Natural chicken intestinal peptide; agonist of NTS1/NTS2 receptors.
Storage Conditions	Store desiccated at -20°C to -80°C; avoid repeated freeze-thaw, moisture, and light. Stable for 1–2 years under proper storage
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog functions as a ligand for neurotensin receptors (NTS1 and NTS2). The substitutions of Lys⁸ and Asn⁹ (replacing the native residues in the NT(8-13) sequence) are strategically located within the receptor-binding pharmacophore. These changes are intended to modulate its interaction with the receptor's binding pocket, potentially altering its binding affinity, selectivity between NTS1 and NTS2 subtypes, and its functional efficacy .

2.PRODUCT INDICATIONS

This product is indicated for advanced research in neuropharmacology and medicinal chemistry focused on the neurotensin system. Key applications include: investigating the structure-activity relationship (SAR) of neurotensin analogs, specifically the role of residues at positions 8 and 9; studying receptor subtype selectivity (NTS1 vs. NTS2); evaluating the effects of these substitutions on peptide stability and in vivo activity; and serving as a key compound in the rational design and screening of novel neurotensin receptor ligands with optimized properties.

3.CLINICAL EFFICACY OF PRODUCT

[Lys⁸,Asn⁹] LANT-6 (8-13) is a research probe for drug discovery, not a clinical therapeutic. Its "efficacy" is defined by its utility in mapping the chemical space around the neurotensin pharmacophore. Research using such site-directed analogs provides critical data on which amino acid residues are permissive for changes and how specific substitutions affect receptor interaction.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.