[Trp11] Neurotensin (8-13) CAS NO.39379-15-2

[Trp¹¹]-Neurotensin (8-13) (CAS NO. 39379-15-2) is a synthetic, site-specifically modified analog of the core active hexapeptide fragment of neurotensin. This research-grade peptide features a tryptophan substitution at position 11, replacing the native amino acid within the critical C-terminal sequence. This modification is designed to probe the structural requirements for receptor binding and activity, and may also incorporate a fluorophore-like property for detection, making it a valuable tool for neurotensin receptor pharmacology and structure-activity relationship studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Trp¹¹] Neurotensin (8-13)
CAS NO.	39379-15-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C40H65N13O7
Molecular Weight	840.05/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (up to 5 mg/mL), 1% dilute acetic acid, DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Modulates central nervous system dopamine signaling, pain perception and gastrointestinal motility; retains core neurotensin-like bioactivity with structural modification
Storage Conditions	Store desiccated at -20°C to -80°C in a sealed vial.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog acts as a ligand for neurotensin receptors (NTS1 and NTS2). The aromatic, bulky side chain of tryptophan at position 11 alters the peptide's conformation and electronic properties compared to the native sequence. This substitution is likely to modulate its interaction with the receptor's binding pocket, potentially affecting binding affinity, receptor subtype selectivity (between NTS1 and NTS2), and functional efficacy (e.g., agonism vs. partial agonism).

2.PRODUCT INDICATIONS

This product is indicated for advanced research in peptide chemistry and neuropharmacology. Key applications include: investigating the structure-activity relationship (SAR) of neurotensin by exploring the role of specific residues in the (8-13) core; studying the impact of aromatic substitutions on receptor binding and activation; potentially serving as a fluorescent probe (if Trp fluorescence is utilized) in receptor localization or binding studies; and as a key compound in the rational design and screening of novel neurotensin receptor modulators with tailored properties.

3.CLINICAL EFFICACY OF PRODUCT

[Trp¹¹]-Neurotensin (8-13) is a molecular research probe, not a clinical therapeutic. Its efficacy lies in its role in fundamental drug discovery science. By systematically modifying the core neurotensin sequence, researchers can map the chemical features essential for receptor interaction. Data from studies with such analogs are critical for constructing detailed pharmacophore models of the neurotensin receptors.

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