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Xenopsin-Related Peptide 2 (XP-2)

Xenopsin-Related Peptide 2 (XP-2) is a bioactive nonapeptide originally isolated from amphibian skin secretions, with the sequence H-Pro-Gly-Pro-Pro-Ile-Ser-Pro-Leu-NH₂ and a molecular weight of approximately 598.7 Da. Supplied as a high-purity lyophilized powder, XP-2 is structurally related to xenopsin and neurotensin family peptides and serves as a research tool for investigating gut-brain axis signaling, gastrointestinal motility, and neuromodulatory pathways. Its conserved proline-rich structure and C-terminal amidation contribute to receptor recognition and stability, making it valuable for comparative physiology and peptide pharmacology studies across species.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Xenopsin-Related Peptide 2 (XP-2)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C60H88N16O10
Molecular Weight	1193.47g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	XP-2 is a bioactive peptide originally identified in amphibians, with roles in gastrointestinal regulation and neuromodulation. It may interact with specific GPCRs related to neurotensin/neuromedin receptors. Biological activity should be validated in relevant receptor binding or functional assays
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

XP-2 exerts its biological effects primarily through interaction with G protein-coupled receptors (GPCRs) related to the neurotensin/neuromedin receptor family, though its exact receptor subtype specificity remains under characterization. Binding to these receptors triggers intracellular signaling cascades, including modulation of cAMP and calcium mobilization, leading to smooth muscle contraction or relaxation in the gastrointestinal tract and potential neuromodulatory effects in the central nervous system. The peptide's proline-rich sequence and C-terminal amidation enhance its resistance to proteolytic degradation, prolonging its half-life and biological activity in experimental systems compared to linear analogs.

2.PRODUCT INDICATIONS

XP-2 is indicated for research applications in gastrointestinal physiology, neuroendocrinology, and comparative peptide biology. It is used in in vitroassays with smooth muscle preparations and receptor-expressing cell lines to study gut motility, secretion, and receptor activation profiles. In in vivomodels, XP-2 is administered to investigate its effects on feeding behavior, stress responses, and gut-brain communication, particularly in the context of amphibian-mammalian evolutionary comparisons. The peptide also serves as a reference standard for structure-activity relationship studies, receptor autoradiography, and the development of novel neurotensin-like analogs for therapeutic targeting.

3.CLINICAL EFFICACY OF PRODUCT

XP-2 has no established clinical efficacy, safety profile, or regulatory approval for human use. Preclinical studies in amphibian and mammalian models have demonstrated its ability to modulate gastrointestinal motility and potentially influence neuroendocrine responses, but these findings are exploratory and limited to basic research contexts. No controlled clinical trials have been conducted to evaluate its therapeutic potential or adverse effects in humans, and its translation to clinical applications is hindered by insufficient pharmacokinetic and toxicological data. The peptide remains strictly a research reagent for investigative purposes without validated diagnostic or therapeutic indications.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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