WWamide-3

WWamide-3 is a synthetic amidated tripeptide with the sequence pGlu-Phe-Trp-NH₂ and a molecular weight of approximately 557.6 Da, supplied as a high-purity lyophilized powder for research use. Originally identified in invertebrates, this neuropeptide is structurally characterized by its N-terminal pyroglutamate and C-terminal amidation, which enhance stability and receptor binding affinity. WWamide-3 serves as a key tool compound for studying feeding behavior, satiety signaling, and neuroendocrine regulation in invertebrate models, with emerging interest in its potential cross-species roles in metabolic and neuromodulatory pathways.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	WWamide-3
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C46H66N12O9S
Molecular Weight	963.18g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	WWamide-3 is a bioactive amidated tripeptide known to be involved in the regulation of feeding behavior and neuromodulation in invertebrates. It may interact with specific GPCRs, potentially influencing satiety and metabolic pathways. Biological activity should be validated in relevant functional assays.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

WWamide-3 exerts its biological effects primarily through activation of G protein-coupled receptors (GPCRs) belonging to the neuropeptide Y/neuropeptide FF receptor superfamily in invertebrates. Binding to these receptors triggers intracellular signaling cascades, including inhibition of adenylate cyclase and modulation of calcium mobilization, leading to altered neuronal excitability and neurosecretion. The peptide's pyroglutamate modification and C-terminal amidation confer resistance to proteolytic degradation, prolonging its half-life and enhancing its potency in modulating feeding circuits and energy homeostasis pathways in experimental systems.

2.PRODUCT INDICATIONS

WWamide-3 is indicated exclusively for research applications in invertebrate neurobiology, comparative endocrinology, and metabolic studies. It is used in in vitroreceptor binding assays and functional screenings to characterize neuropeptide receptor pharmacology and signaling mechanisms. In in vivomodels, the peptide is administered to investigate its effects on feeding behavior, satiety, and metabolic regulation in insects, mollusks, and other invertebrates. WWamide-3 also serves as a reference standard for structure-activity relationship studies and the development of novel neuropeptide analogs targeting feeding and metabolic disorders.

3.CLINICAL EFFICACY OF PRODUCT

WWamide-3 has no established clinical efficacy, safety profile, or regulatory approval for human or veterinary therapeutic use. Preclinical studies in invertebrate models have demonstrated its ability to modulate feeding behavior and energy balance, but these findings are exploratory and limited to basic research contexts. No controlled clinical trials have been conducted to evaluate its therapeutic potential or adverse effects in humans or animals, and its translation to clinical applications is precluded by insufficient pharmacokinetic and toxicological data. The peptide remains strictly a research reagent for investigative purposes without validated diagnostic or therapeutic indications.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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