Valorphin CAS NO.144313-54-2

Valorphin is a synthetic heptapeptide (H-Val-Val-Tyr-Pro-Trp-Thr-Gln-NH₂) derived from the β-chain of hemoglobin, with a molecular weight of approximately 560.7 Da and CAS number 144313-54-2. Supplied as a high-purity lyophilized powder, it belongs to the hemorphin family and serves as a research tool for studying opioid receptor interactions, neuroimmune signaling, and inflammatory pathways. Its structure includes key residues for receptor recognition and stability, making it valuable for investigating pain modulation, immune regulation, and the cross-talk between the nervous and immune systems in preclinical models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Valorphin
CAS NO.	144313-54-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C44H61N9O11
Molecular Weight	892.03g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Valorphin is a heptapeptide derived from hemoglobin β-chain, exhibiting opioid receptor binding and potential immunomodulatory activity. It is primarily used in research on neuroimmunology, pain modulation, and inflammation.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Valorphin exerts its biological effects primarily through binding to opioid receptors, particularly μ- and δ-opioid receptors, acting as an opioid peptide agonist. Activation of these G protein-coupled receptors leads to inhibition of adenylate cyclase, reduction in cAMP levels, and modulation of ion channel activity, resulting in analgesic and anti-nociceptive effects. Additionally, Valorphin may influence immune cell function and cytokine production through opioid receptor-mediated signaling, contributing to its immunomodulatory properties observed in experimental systems, though its exact receptor subtype selectivity and downstream pathways remain under characterization.

2.PRODUCT INDICATIONS

Valorphin is indicated for research applications in neuropharmacology, immunology, and pain research. It is used in in vitroassays, such as receptor binding studies and functional screenings, to characterize opioid receptor pharmacology and signaling mechanisms. In in vivomodels, the peptide is administered to investigate its effects on pain perception, inflammation, and neuroimmune interactions, providing insights into the role of hemorphins in disease pathophysiology. Valorphin also serves as a reference compound for structure-activity relationship studies and the development of novel opioid-based therapeutics targeting pain and inflammatory disorders.

3.CLINICAL EFFICACY OF PRODUCT

Valorphin has no established clinical efficacy, safety profile, or regulatory approval for human use. Preclinical studies have demonstrated its opioid receptor-mediated analgesic and potential immunomodulatory effects in animal models, but these findings are exploratory and limited to basic research. No controlled clinical trials have been conducted to evaluate its therapeutic benefits, dosing regimens, or adverse effects in humans, and its translation to clinical applications is hindered by insufficient pharmacokinetic, toxicological, and long-term safety data. The peptide remains strictly a research reagent for investigative purposes without validated diagnostic or therapeutic indications.

4.DELIVERY & SHIPPING

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