Leu-Valorphin-Arg CAS NO.135861-77-7

Leu-Valorphin-Arg (CAS NO. 135861-77-7) is a synthetic tetrapeptide with the sequence Leu-Val-Val-Tyr-Arg-NH2 (based on standard nomenclature where "Leu-Valorphin" implies a core structure extended with an Arg residue). It is a modified analog derived from the valorphin/hemorphin family of peptides, which are bioactive fragments originating from hemoglobin. This research-grade compound is designed for studying opioid and non-opioid peptide signaling, particularly in relation to cardiovascular and neurological functions.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Leu-Valorphin-Arg
CAS NO.	135861-77-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C56H84N14O13
Molecular Weight	1161.38/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥20 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Opioid receptor agonist (high affinity for μ-opioid receptors); exhibits analgesic activity and modulates pain signaling pathways
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide is believed to exert its effects through interactions with opioid receptors (likely μ and/or δ subtypes), given its structural relationship to valorphin/hemorphin peptides known for opioid activity. The addition of the C-terminal arginine may influence its receptor affinity, selectivity, and metabolic stability. Upon receptor binding, it may modulate G protein-coupled signaling pathways, leading to effects such as analgesia, modulation of blood pressure, and potential influence on angiotensin-converting enzyme (ACE) activity, contributing to cardiovascular regulation.

2.PRODUCT INDICATIONS

This product is indicated for specialized research in neuropharmacology and cardiovascular physiology. Key applications include: investigating the structure-activity relationships (SAR) of hemorphin/valorphin-derived peptides and their effects on opioid receptors; studying its potential modulatory effects on blood pressure and vascular tone; exploring interactions with the renin-angiotensin system (RAS), possibly as an ACE inhibitor substrate or modifier; and serving as a tool peptide in the development of novel bioactive peptides with dual opioid and cardiovascular activities.

3.CLINICAL EFFICACY OF PRODUCT

Leu-Valorphin-Arg is a research peptide and not an approved drug. Its efficacy is defined by its role as a molecular tool in basic science. Research on such modified hemorphin analogs contributes to understanding how small peptide fragments from ubiquitous proteins like hemoglobin can regulate complex physiological systems. This knowledge could pave the way for the design of novel multitarget therapeutics that combine opioid-mediated effects with cardiovascular benefits , although this remains in the exploratory research phase.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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