english

Adrenorphin, Free Acid CAS NO.88866-92-6

Adrenorphin, Free Acid is a synthetic opioid octapeptide with the sequence H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-OH and a molecular weight of approximately 587.7 Da , supplied as a high-purity lyophilized powder in its free acid form. Derived from proenkephalin A, this endogenous peptide serves as a research tool for studying opioid receptor pharmacology, pain signaling, and neuroendocrine regulation. Its C-terminal free carboxyl group distinguishes it from amidated analogs, providing a reference compound for structure-activity relationship studies and functional assays in neurobiology and pharmacology.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Adrenorphin, Free Acid
CAS NO.	88866-92-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C44H68N14O10S
Molecular Weight	985.18g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Adrenorphin is an endogenous opioid peptide derived from proenkephalin A. It acts as an agonist at μ-opioid and δ-opioid receptors, exhibiting analgesic and neuroendocrine regulatory activity. Biological activity is typically confirmed in opioid receptor binding or functional assays (e.g., cAMP inhibition).
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Adrenorphin, Free Acid exerts its biological effects through agonist activity at μ-opioid and δ-opioid receptors, acting as a G protein-coupled receptor ligand. Binding to these receptors inhibits adenylate cyclase, reduces intracellular cAMP levels, and modulates potassium and calcium channel activity, leading to neuronal hyperpolarization and reduced neurotransmitter release. This signaling cascade underlies its analgesic, anti-nociceptive, and neuroendocrine regulatory properties observed in experimental systems, with the free acid form allowing investigation of C-terminal modifications on receptor affinity and metabolic stability.

2.PRODUCT INDICATIONS

Adrenorphin, Free Acid is indicated exclusively for research applications in opioid receptor pharmacology, pain research, and neuroendocrinology. It is used in in vitroassays such as receptor binding studies, functional screenings (e.g., cAMP inhibition, electrophysiology), and structure-activity relationship investigations to characterize opioid peptide-receptor interactions. In in vivomodels, the peptide is administered to study its effects on pain perception, stress responses, and neuroendocrine function, providing insights into endogenous opioid systems and potential therapeutic targets for pain and neuropsychiatric disorders.

3.CLINICAL EFFICACY OF PRODUCT

Adrenorphin, Free Acid has no established clinical efficacy, safety profile, or regulatory approval for human use. Preclinical studies have demonstrated its opioid receptor-mediated analgesic and neuroendocrine effects in animal models, but these findings are exploratory and limited to basic research. No controlled clinical trials have been conducted to evaluate its therapeutic benefits, pharmacokinetics, or adverse effects in humans, and its translation to clinical applications is precluded by insufficient toxicological and long-term safety data. The peptide remains strictly a research reagent for investigative purposes without validated diagnostic or therapeutic indications.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.