Adrenorphin CAS NO.88377-68-8

Adrenorphin (CAS NO. 88377-68-8) is a synthetic, amidated octapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH₂) derived from the proenkephalin A precursor. This research-grade opioid peptide is a potent endogenous agonist for μ-opioid and δ-opioid receptors. It serves as a crucial tool for studying opioidergic neurotransmission, pain modulation, and stress-related physiological responses.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Adrenorphin
CAS NO.	88377-68-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C44H69N15O9S
Molecular Weight	984.2/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥25 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Selective opioid receptor agonist (high affinity for μ and κ-opioid receptors); exhibits potent analgesic activity, modulates stress and pain signaling pathways
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Adrenorphin exerts its biological effects by binding with high affinity to μ-opioid (MOP) and δ-opioid (DOP) receptors in the central and peripheral nervous systems. Upon binding, it activates inhibitory Gi/o proteins, leading to the inhibition of adenylate cyclase, reduced cAMP production, and subsequent modulation of ion channels (e.g., opening of potassium channels, closing of calcium channels).

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in neuropharmacology and pain biology. Key applications include: studying the pharmacology of μ- and δ-opioid receptors and their downstream signaling pathways; investigating endogenous opioid systems in pain modulation and stress responses; exploring adrenorphin's role in addiction, reward, and emotional behavior; and serving as a potent reference agonist in opioid receptor binding assays and functional studies for screening and characterizing novel opioid ligands.

3.CLINICAL EFFICACY OF PRODUCT

Adrenorphin is a research tool and not used directly in clinical therapy. However, its "efficacy" as a potent endogenous opioid peptide has made it a valuable probe for understanding the opioid system. Research using adrenorphin has contributed to mapping the physiological roles of opioid receptors, particularly in pain and stress pathways. This foundational knowledge is critical for the ongoing development of safer and more effective opioid analgesics, as well as for understanding the mechanisms underlying opioid tolerance, dependence, and addiction, which are major challenges in pain management.

4.DELIVERY & SHIPPING

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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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