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Universal TT epitope P2 (830-844)

Universal TT Epitope P2 (830-844) is a synthetic 15-amino acid peptide corresponding to residues 830-844 of the Tetanus Toxoid (TT) protein. This high-purity peptide represents a well-characterized, universal T-helper (Th) cell epitope that binds promiscuously to multiple Major Histocompatibility Complex (MHC) Class II molecules across diverse human populations. It is a fundamental research and vaccine development tool used to enhance and modulate antigen-specific immune responses.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Universal TT epitope P2 (830-844) (Tetanus Toxin Epitope P2 (830-844)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C80H129N19O23
Molecular Weight	11725.03/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥5 mg/mL), dilute acetic acid; soluble in DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Promiscuous CD4⁺ T-cell epitope derived from tetanus toxin (residues 830-844); binds to diverse HLA-DRB molecules.
Storage Conditions	Store at -20°C to -80°C in dry, dark environment; avoid repeated freeze-thaw cycles; ship at 4°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as a potent CD4+ T-helper cell epitope. Antigen-presenting cells (APCs), such as dendritic cells, process and load this peptide onto MHC Class II molecules. The peptide-MHC II complex is presented on the APC surface to naïve CD4+ T-cells bearing complementary T-cell receptors (TCRs). This interaction, along with appropriate co-stimulation, activates the CD4+ T-cells.

2.PRODUCT INDICATIONS

This product is indicated for immunology research and vaccine/diagnostic development. Key applications include: serving as a universal T-helper epitope in conjugate or multi-epitope vaccine constructs to enhance the immunogenicity of weakly immunogenic antigens (e.g., peptides, polysaccharides); used as a positive control in T-cell proliferation and cytokine release assays (e.g., ELISpot) to monitor general T-helper cell responsiveness; as a tool to study MHC Class II binding promiscuity and antigen presentation; and in the development of immunodiagnostics to assess general T-cell memory against tetanus vaccination.

3.CLINICAL EFFICACY OF PRODUCT

As a research and development tool, the Universal TT Epitope P2 itself is not a standalone therapeutic. Its clinical "efficacy" is demonstrated through its integral role in modern vaccine design. By incorporating this epitope into vaccine candidates, developers can significantly enhance the strength, breadth, and durability of the immune response against the target pathogen. This strategy is used to improve vaccines for infectious diseases and cancers, ensuring robust immunological memory. Its use as a positive control in immune monitoring also aids in clinical trials to assess patient immunocompetence.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.