Neuromedin U-25 CAS NO.312306-89-1
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neuromedin U-25 |
| CAS NO. | 312306-89-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₂₁H₁₉₀N₃₆O₃₁S |
| Molecular Weight | 2736.1 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water, dilute acetic acid, or DMSO |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Exhibits potent contractile activity on smooth muscle (e.g., rat uterus and bladder); activates NMUR1 and NMUR2 receptors with high affinity. |
| Storage Conditions | Store at -20°C to -80°C; avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 24 months at -20°C. Reconstituted solution should be stored at -20°C and used within 3 months. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Neuromedin U-25 exerts its diverse physiological effects by binding to and activating two G protein-coupled receptors, NMUR1 (primarily peripheral) and NMUR2 (primarily central). Upon receptor binding, it primarily activates the Gq/11 protein signaling pathway. This leads to phospholipase C (PLC) activation, inositol trisphosphate (IP₃) production, and diacylglycerol (DAG) formation, resulting in a rapid increase in intracellular calcium concentrations. This signaling mediates its potent anorexigenic (appetite-suppressing) effects, influences smooth muscle contraction in the gut and uterus, modulates blood pressure, and regulates stress-related hormone release.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
Neuromedin U-25 (rat) is a research tool, not a human therapeutic. Its efficacy is demonstrated in robust preclinical models that have validated the NMU system as a significant regulator of energy balance. Research using this peptide has consistently shown its potent ability to reduce food intake and body weight in rodents, highlighting its potential as a novel target for anti-obesity drug development. Additionally, studies on its peripheral effects inform potential applications in gastrointestinal motility disorders and hypertension. These findings drive translational research into NMU receptor modulators for metabolic and other disorders.
4.DELIVERY & SHIPPING
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Neuromedin U-25 benefits
Neuromedin U 25 (NMU 25) is a neuropeptide consisting of 25 amino acids that plays a vital role in regulating multiple physiological processes in both the central and peripheral nervous systems. One of its primary functions is the regulation of appetite and energy balance. NMU 25 acts on its specific G protein-coupled receptors, NMUR1 and NMUR2, to suppress food intake and promote satiety, making it an important peptide in studies of obesity, metabolism, and weight management. By influencing hypothalamic pathways in the brain, NMU 25 contributes to metabolic homeostasis and can modulate energy expenditure, supporting overall body weight regulation.
In addition to its metabolic effects, NMU 25 exerts significant influence on the cardiovascular system. It has been shown to induce vasoconstriction and regulate blood pressure, suggesting potential roles in circulatory system function and vascular health. Furthermore, NMU 25 can stimulate smooth muscle contraction, including in the gastrointestinal tract and uterus, which highlights its involvement in organ motility and reproductive physiology. These actions demonstrate its broad impact beyond neural signaling, bridging multiple organ systems.
Recent research has also identified a role for NMU 25 in the immune system, particularly in promoting type 2 immune responses. It can activate and recruit specific immune cells, such as eosinophils and type 2 lymphocytes, which may be relevant in allergic inflammation, asthma, and other immune-mediated conditions. This emerging evidence positions NMU 25 as a multifunctional peptide with both regulatory and protective roles in human physiology.
Because of its wide-ranging effects, NMU 25 is of great interest in biomedical research and therapeutic development. Scientists are investigating its potential as a target for treating metabolic disorders, cardiovascular diseases, gastrointestinal dysfunctions, and inflammatory conditions. Its ability to modulate appetite, energy balance, vascular tone, and immune responses makes it a unique peptide with promising clinical relevance.
In summary, Neuromedin U 25 is a multifunctional neuropeptide that contributes to appetite suppression, energy regulation, cardiovascular control, smooth muscle function, and immune modulation. Its diverse physiological roles and therapeutic potential make it a key molecule in understanding complex interactions between the nervous, metabolic, and immune systems, and a promising target for future medical research and interventions.
What is the CAS number of Neuromedin U-25
Neuromedin U 25 (NMU 25) is a biologically active neuropeptide consisting of 25 amino acids, originally isolated from mammalian spinal cord and named for its “U-shaped” sequence structure. It plays critical roles in multiple physiological systems, including appetite regulation, energy homeostasis, cardiovascular control, smooth muscle contraction, and immune modulation. Due to its importance in biomedical research and therapeutic studies, NMU 25 is cataloged with a Chemical Abstracts Service (CAS) number, which provides a unique identifier for unambiguous reference in scientific literature and commercial databases. For human Neuromedin U 25, the CAS number is 312306 89 1, while other species variants, such as porcine NMU 25, may have separate CAS numbers, for example 98395 76 7. These identifiers are essential for researchers and formulators to ensure the correct peptide is sourced for laboratory experiments, receptor-binding studies, or physiological assays.
The CAS number allows NMU 25 to be tracked across chemical inventories, peptide suppliers, and scientific publications, facilitating reproducibility in research. By referencing CAS 312306 89 1, scientists can obtain consistent synthetic or recombinant human NMU 25 for studies involving G protein-coupled receptors NMUR1 and NMUR2, which mediate its diverse effects. NMU 25’s functions include suppressing food intake, modulating energy expenditure, promoting smooth muscle contraction in the gastrointestinal tract and uterus, regulating blood pressure, and influencing type 2 immune responses. These broad actions make it a versatile peptide in both neuroscience and metabolic research, as well as in investigations of inflammatory and cardiovascular physiology.
Because of its multiple bioactivities, NMU 25 is used in preclinical studies exploring potential therapeutic applications, such as treatments for obesity, metabolic disorders, hypertension, and allergic inflammation. The CAS number ensures researchers can precisely identify and reference the peptide, avoiding confusion with other neuromedins or shorter NMU fragments, which may differ in biological activity. In summary, the CAS number 312306 89 1 for human Neuromedin U 25 serves as a critical tool for scientific communication, supply chain accuracy, and research reproducibility, supporting the ongoing study of this multifunctional neuropeptide across metabolic, cardiovascular, and immune system research.
What is Neuromedin U-25
Neuromedin U 25 (NMU 25) is a biologically active neuropeptide composed of 25 amino acids, originally identified in the mammalian spinal cord. It belongs to the neuromedin peptide family and is named “U” for its distinctive structural motif. NMU 25 exerts a wide range of physiological effects through its specific G protein-coupled receptors, NMUR1 and NMUR2, which are distributed in both peripheral tissues and the central nervous system. By binding to these receptors, NMU 25 participates in the regulation of appetite, energy balance, cardiovascular function, smooth muscle contraction, and immune responses, making it a multifunctional signaling molecule essential for maintaining homeostasis.
One of the most studied roles of NMU 25 is its regulation of food intake and energy metabolism. Acting primarily in the hypothalamus, it suppresses appetite and promotes satiety, influencing body weight and energy expenditure. This anorexigenic property makes NMU 25 a significant target for research into obesity, metabolic disorders, and related therapeutic strategies. Additionally, NMU 25 can influence vascular tone and blood pressure through its vasoconstrictive effects, as well as stimulate smooth muscle contraction in organs such as the gastrointestinal tract and uterus, highlighting its diverse physiological impact.
Emerging research also emphasizes NMU 25’s role in the immune system, where it modulates type 2 immune responses by activating and recruiting immune cells such as eosinophils and lymphocytes. This suggests potential relevance in allergic inflammation, asthma, and other immune-mediated conditions. Due to its broad physiological roles, NMU 25 is widely used in biomedical research, particularly in studies investigating neuroendocrine signaling, metabolic regulation, cardiovascular physiology, and immune modulation.
Overall, Neuromedin U 25 is a multifunctional neuropeptide with important regulatory functions across multiple body systems. Its ability to modulate appetite, metabolism, cardiovascular function, smooth muscle activity, and immune responses makes it a critical molecule for understanding complex physiological interactions. As research continues, NMU 25 holds promise not only for advancing our knowledge of fundamental biology but also for developing potential therapies for metabolic, cardiovascular, and inflammatory disorders.
