Substance P (1-7) CAS NO.68060-49-1

Substance P (1-7) (CAS NO. 68060-49-1) is a synthetic heptapeptide representing the N-terminal fragment of the full-length neuropeptide Substance P. This research-grade peptide (Arg-Pro-Lys-Pro-Gln-Gln-Phe) is a bioactive metabolite generated from the enzymatic cleavage of native Substance P. It exhibits a distinct and often opposing pharmacological profile compared to its parent peptide, serving as a crucial tool for studying pain modulation, neuroinflammation, and the complex metabolism of tachykinins.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Substance P (1-7)
CAS NO.	68060-49-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C₃₉H₅₅N₁₁O₁₀S
Molecular Weight	885.99 g /mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Exhibits partial agonist activity at neurokinin receptors (NK1, NK2, NK3); involved in modulating inflammatory responses and neuronal signaling.
Storage Conditions	Store at -20°C to -80°C; avoid repeated freeze-thaw cycles. Lyophilized powder is stable for up to 24 months at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Substance P (1-7) acts as an endogenous ligand with a unique mechanism that modulates the effects of full-length Substance P. It does not activate the primary Neurokinin 1 (NK1) receptor like its parent peptide. Instead, it is believed to exert its effects through interaction with specific, yet not fully characterized, receptors or binding sites distinct from NK1. Its actions often function as a functional antagonist to Substance P, potentially by inhibiting Substance P's release, enhancing its degradation, or activating counter-regulatory pathways. This leads to observed effects such as anti-nociception (pain relief), reduction of opioid withdrawal symptoms, and modulation of neurogenic inflammation.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in neuropharmacology, pain biology, and addiction science. Key applications include: investigating the physiological role of Substance P metabolism and the balance between its N-terminal and C-terminal fragments; studying its anti-nociceptive and anti-allodynic effects in models of acute and chronic pain; exploring its ability to modulate opioid tolerance and withdrawal symptoms; serving as a tool to differentiate between NK1-mediated and non-NK1-mediated effects of the tachykinin system; and research into neuroinflammatory and neurodegenerative conditions.

3.CLINICAL EFFICACY OF PRODUCT

Substance P (1-7) is a research metabolite and not a clinical drug. Its efficacy is demonstrated in preclinical studies highlighting its significant therapeutic potential. Research shows that this fragment can attenuate pain, reduce neurogenic inflammation, and alleviate symptoms of opioid withdrawal in animal models. These findings suggest that enhancing the natural formation of Substance P (1-7) or developing stable analogs could represent a novel therapeutic strategy for chronic pain management, opioid dependence, and inflammatory disorders, offering an alternative pathway that avoids the pro-inflammatory effects of Substance P.

4.DELIVERY & SHIPPING

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