Substance P (1-9) CAS NO.57468-17-4

Substance P (1-9) (CAS NO. 57468-17-4) is a synthetic, nonapeptide representing the N-terminal fragment of the full-length neuropeptide Substance P. This research-grade peptide (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly) lacks the C-terminal amide group crucial for high-affinity NK1 receptor binding. It serves as an important metabolite and pharmacological tool for studying Substance P degradation, metabolism, and the distinct biological roles of its N-terminal fragments.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Substance P (1-9)
CAS NO.	57468-17-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C₅₁H₇₁N₁₅O₁₃S
Molecular Weight	1162.28 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Acts as a partial agonist at neurokinin receptors (primarily NK1), modulates neuronal excitability and inflammatory responses; exhibits reduced potency compared to full-length Substance P.
Storage Conditions	Store at -20°C to -80°C in a dry environment. Lyophilized powder is stable for 24 months at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Substance P (1-9) is primarily characterized by its lack of agonist activity at the classical Neurokinin 1 (NK1) receptor. Its mechanism of action is distinct from the parent peptide. It is believed to interact with alternative, less-defined binding sites or receptors. Its biological effects may be mediated through modulation of other neurotransmitter systems or by acting as a functional antagonist, potentially interfering with the actions of full-length Substance P or other tachykinins. Studies suggest it may influence processes like angiogenesis, immune modulation, and neuroprotection, independent of the canonical NK1 receptor pathway.

2.PRODUCT INDICATIONS

This product is indicated for specialized research in neuropharmacology, peptide metabolism, and vascular biology. Key applications include: studying the enzymatic degradation pathways of Substance P and the biological activity of its N-terminal metabolites; investigating the non-NK1 receptor-mediated effects of the tachykinin system; exploring its potential roles in angiogenesis, neuroprotection, and neuroinflammation; and using it as a control or reference peptide in assays to distinguish NK1-dependent and NK1-independent effects of Substance P and related peptides.

3.CLINICAL EFFICACY OF PRODUCT

Substance P (1-9) is a research metabolite and not a clinical therapeutic. Its efficacy is demonstrated through its role in revealing the complex biology of Substance P beyond NK1 receptor activation. Preclinical research suggests that N-terminal fragments like Substance P (1-9) may possess beneficial properties, such as promoting angiogenesis or exerting neuroprotective effects in certain contexts. Understanding the formation and function of these metabolites is crucial for a complete picture of the tachykinin system's role in health and disease, potentially informing future therapeutic strategies that target specific metabolic pathways rather than just receptor blockade.

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